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  • Increased Biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae

    Author(s)
    Vanderlelie, J
    Venardos, K
    Clifton, VL
    Gude, NM
    Clarke, FM
    Perkins, AV
    Griffith University Author(s)
    Clarke, Francis M.
    Year published
    2005
    Metadata
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    Abstract
    Oxidative stress occurs when cellular levels of reactive oxygen species exceed anti-oxidant capabilities and has been implicated in the pathogenesis of pre-eclampsia. In this study we have examined the tissue levels of endogenous anti-oxidant proteins (superoxide dismutase, glutathione peroxidase, thioredoxin reductase and thioredoxin) and the level of lipid and protein oxidation in placental samples from normal and pre-eclamptic pregnancies. Pre-eclamptic tissue homogenates demonstrated significantly increased levels of lipid peroxidation ( protein versus protein, P<0.001) and a trended increase in protein carbonyl ...
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    Oxidative stress occurs when cellular levels of reactive oxygen species exceed anti-oxidant capabilities and has been implicated in the pathogenesis of pre-eclampsia. In this study we have examined the tissue levels of endogenous anti-oxidant proteins (superoxide dismutase, glutathione peroxidase, thioredoxin reductase and thioredoxin) and the level of lipid and protein oxidation in placental samples from normal and pre-eclamptic pregnancies. Pre-eclamptic tissue homogenates demonstrated significantly increased levels of lipid peroxidation ( protein versus protein, P<0.001) and a trended increase in protein carbonyl concentration ( protein versus protein) when compared to controls. The levels and activities of the anti-oxidant proteins superoxide dismutase ( protein versus protein, P<0.02), thioredoxin reductase ( protein versus protein, P=0.02), thioredoxin ( protein versus protein, P=0.02) and glutathione peroxidase ( protein versus , P<0.02) were all found to be significantly reduced when comparing pre-eclamptic placental tissue homogenates to gestational age-matched control placentae from non-pre-eclamptic pregnancies. The results of this study demonstrate a decreased enzymatic anti-oxidant capacity and increased oxidation in placental tissue from pre-eclamptic women, which may contribute to the pathogenesis of this complex disorder.
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    Journal Title
    Placenta
    Volume
    26
    Publisher URI
    http://www.elsevier.com/wps/find/journaldescription.cws_home/623064/description#description
    DOI
    https://doi.org/10.1016/j.placenta.2004.04.002
    Subject
    Biochemistry and cell biology
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/4778
    Collection
    • Journal articles

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