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dc.contributor.authorVanderlelie, Jessicaen_US
dc.contributor.authorVenardos, Kylieen_US
dc.contributor.authorClifton, V.en_US
dc.contributor.authorGude, N.en_US
dc.contributor.authorClarke, Francisen_US
dc.contributor.authorPerkins, Anthonyen_US
dc.date.accessioned2017-05-03T11:16:57Z
dc.date.available2017-05-03T11:16:57Z
dc.date.issued2005en_US
dc.date.modified2009-12-07T03:34:52Z
dc.identifier.issn01434004en_US
dc.identifier.doi10.1016/j.placenta.2004.04.002en_AU
dc.identifier.urihttp://hdl.handle.net/10072/4778
dc.description.abstractOxidative stress occurs when cellular levels of reactive oxygen species exceed anti-oxidant capabilities and has been implicated in the pathogenesis of pre-eclampsia. In this study we have examined the tissue levels of endogenous anti-oxidant proteins (superoxide dismutase, glutathione peroxidase, thioredoxin reductase and thioredoxin) and the level of lipid and protein oxidation in placental samples from normal and pre-eclamptic pregnancies. Pre-eclamptic tissue homogenates demonstrated significantly increased levels of lipid peroxidation ( protein versus protein, P<0.001) and a trended increase in protein carbonyl concentration ( protein versus protein) when compared to controls. The levels and activities of the anti-oxidant proteins superoxide dismutase ( protein versus protein, P<0.02), thioredoxin reductase ( protein versus protein, P=0.02), thioredoxin ( protein versus protein, P=0.02) and glutathione peroxidase ( protein versus , P<0.02) were all found to be significantly reduced when comparing pre-eclamptic placental tissue homogenates to gestational age-matched control placentae from non-pre-eclamptic pregnancies. The results of this study demonstrate a decreased enzymatic anti-oxidant capacity and increased oxidation in placental tissue from pre-eclamptic women, which may contribute to the pathogenesis of this complex disorder.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherW.B Saundersen_US
dc.publisher.placeUKen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/623064/description#descriptionen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom53en_US
dc.relation.ispartofpageto58en_US
dc.relation.ispartofjournalPlacentaen_US
dc.relation.ispartofvolume26en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270199en_US
dc.titleIncreased Biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentaeen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.date.issued2005
gro.hasfulltextNo Full Text


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