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dc.contributor.authorMylrea, M
dc.contributor.authorRobertson, S
dc.contributor.authorHaywood, A
dc.contributor.authorGlass, B
dc.date.accessioned2017-05-03T14:23:27Z
dc.date.available2017-05-03T14:23:27Z
dc.date.issued2012
dc.date.modified2013-06-18T00:24:26Z
dc.identifier.issn1445-937X
dc.identifier.urihttp://hdl.handle.net/10072/47803
dc.description.abstractBackground: Although guidelines indicate that dispersible aspirin tablets should not be repacked into dose administration aids, it is common practice especially among older people. Aim: To determine the stability of acetylsalicylic acid (ASA) in aspirin tablets repacked into Dosette boxes. Method: Dispersible aspirin 300 mg tablets were removed from their primary (foil) packaging, and repacked as whole and split (halved) tablets into Dosette boxes under 4 storage conditions: refrigeration (2-8 ꃩ, controlled room temperature (25 ꃻ 60% relative humidity [RH]), accelerated (40 ꃻ 75% RH), and 'in-use' with natural variations in daylight exposure and internal temperature fluctuations (23-26 ꃻ 45-60% RH) for 1 week. The high performance liquid chromatography method developed was validated for accuracy, precision, linearity and range, sensitivity, robustness and specificity, and the suitability of extraction media evaluated. Results: Linearity (r2 > 0.999), precision (relative standard deviation < 2%) accuracy (recovery: 95-102%) and selectivity for the high performance liquid chromatography method were confirmed. The ASA content remained within specifications (95-105% of labelled amount) for all except the accelerated storage condition, with 93% of the ASA remaining. The split tablets did not display any additional ASA degradation when compared to the whole tablets under the same conditions. Conclusion: While the ASA content of the dispersible aspirin tablets remained within specifications at room temperature, there were changes in the physical appearance under accelerated storage conditions.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent180086 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherSociety of Hospital Pharmacists of Australia
dc.publisher.placeAustralia
dc.publisher.urihttp://jppr.shpa.org.au
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom204
dc.relation.ispartofpageto207
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Pharmacy Practice and Research
dc.relation.ispartofvolume42
dc.rights.retentionY
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmaceutical sciences
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321405
dc.titleStability of Dispersible Aspirin Tablets Repacked into Dosette Boxes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2012 Journal of Pharmacy Practice and Research. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorHaywood, Alison


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