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  • Diversity-oriented pyrazol-3-one synthesis based on hydrazinodipeptide-like units prepared via the Ugi reaction

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    Author(s)
    Lakontseva, Ekaterina
    Krasavin, Mikhail
    Griffith University Author(s)
    Krasavin, Mikhail
    Year published
    2010
    Metadata
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    Abstract
    N-Cyanoacetyl-N0-trifluoroacetyl-N0-alkylhydrazines, prepared via hydrazino-Ugi reaction, provided different pyrazol-3-ones when exposed to mildly acidic and mildly basic conditions at 60 C. These approaches offer a facile access to two different pyrazol-3-one-containing chemotypes in a diversity-oriented fashion, in only two chemical operations from simple precursors.N-Cyanoacetyl-N0-trifluoroacetyl-N0-alkylhydrazines, prepared via hydrazino-Ugi reaction, provided different pyrazol-3-ones when exposed to mildly acidic and mildly basic conditions at 60 C. These approaches offer a facile access to two different pyrazol-3-one-containing chemotypes in a diversity-oriented fashion, in only two chemical operations from simple precursors.
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    Journal Title
    Tetrahedron Letters
    Volume
    51
    Issue
    31
    DOI
    https://doi.org/10.1016/j.tetlet.2010.05.133
    Copyright Statement
    © 2010 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Organic Chemical Synthesis
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Publication URI
    http://hdl.handle.net/10072/48061
    Collection
    • Journal articles

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