The Abundance of Deleterious Polymorphisms in Humans

Author
Sankarasubramanian, Sankar
Year published
2012
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Abstract
Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs speci?c to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans.
Journal Title
Genetics
Volume
190
Issue
4
DOI
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Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Subject
Evolutionary Biology not elsewhere classified
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