The Abundance of Deleterious Polymorphisms in Humans
Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs speci?c to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans.
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Evolutionary Biology not elsewhere classified