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  • The Abundance of Deleterious Polymorphisms in Humans

    Author(s)
    Sankarasubramanian, Sankar
    Griffith University Author(s)
    Sankarasubramanian, Sankar
    Year published
    2012
    Metadata
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    Abstract
    Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs speci?c to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans.Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs speci?c to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans.
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    Journal Title
    Genetics
    Volume
    190
    Issue
    4
    DOI
    https://doi.org/10.1534/genetics.111.137893
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Evolutionary Biology not elsewhere classified
    Genetics
    Publication URI
    http://hdl.handle.net/10072/48189
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    • Journal articles

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