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  • Synthesis and hydrolysis studies of novel glyco-functionalized platinum complexes

    Author(s)
    Moeker, Janina
    Thiem, Joachim
    Griffith University Author(s)
    Moeker, Janina
    Year published
    2012
    Metadata
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    Abstract
    Cisplatin and some of its derivatives are among the most active cytostatics for cancer treatment. Unfortunately, application of platinum complexes always indicates side effects, and frequently primary or developed resistance of tumour cells appear. Therefore, development of novel analogues especially with natural ligands is expedited. Glyco-functionalized ligands were obtained via ether synthesis with ?-halo ethers, Finkelstein reaction, with further treatment with malonate and final deprotection followed by preparation of the disodium salts. Subsequent complexation led to novel platinum derivatives, the stabilities of which ...
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    Cisplatin and some of its derivatives are among the most active cytostatics for cancer treatment. Unfortunately, application of platinum complexes always indicates side effects, and frequently primary or developed resistance of tumour cells appear. Therefore, development of novel analogues especially with natural ligands is expedited. Glyco-functionalized ligands were obtained via ether synthesis with ?-halo ethers, Finkelstein reaction, with further treatment with malonate and final deprotection followed by preparation of the disodium salts. Subsequent complexation led to novel platinum derivatives, the stabilities of which in aqueous solution media were studied.
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    Journal Title
    Carbohydrate Research
    Volume
    348
    DOI
    https://doi.org/10.1016/j.carres.2011.08.024
    Subject
    Bioinorganic Chemistry
    Organic Chemical Synthesis
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Biochemistry and Cell Biology
    Publication URI
    http://hdl.handle.net/10072/48202
    Collection
    • Journal articles

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