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  • 3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations

    Author(s)
    Banwell, Martin G
    Coster, Mark J
    Hungerford, Natasha L
    Garson, Mary J
    Su, Stephen
    Kotze, Andrew C
    Munro, Murray HG
    Griffith University Author(s)
    Coster, Mark J.
    Hungerford, Natasha L.
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    Compounds 2-5, incorporating various elements of the 3,4'-bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and certain derivatives. Screening of these compounds in various assays, including an ecological one, reveals that compound 5 exhibits allelochemical properties similar to those associated with HA itself.Compounds 2-5, incorporating various elements of the 3,4'-bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and certain derivatives. Screening of these compounds in various assays, including an ecological one, reveals that compound 5 exhibits allelochemical properties similar to those associated with HA itself.
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    Journal Title
    Organic & Biomolecular Chemistry
    Volume
    10
    Issue
    1
    DOI
    https://doi.org/10.1039/C1OB06418E
    Subject
    Medicinal and biomolecular chemistry
    Organic chemistry
    Organic chemical synthesis
    Publication URI
    http://hdl.handle.net/10072/48209
    Collection
    • Journal articles

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