3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations
Author(s)
Banwell, Martin G
Coster, Mark J
Hungerford, Natasha L
Garson, Mary J
Su, Stephen
Kotze, Andrew C
Munro, Murray HG
Year published
2012
Metadata
Show full item recordAbstract
Compounds 2-5, incorporating various elements of the 3,4'-bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and certain derivatives. Screening of these compounds in various assays, including an ecological one, reveals that compound 5 exhibits allelochemical properties similar to those associated with HA itself.Compounds 2-5, incorporating various elements of the 3,4'-bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and certain derivatives. Screening of these compounds in various assays, including an ecological one, reveals that compound 5 exhibits allelochemical properties similar to those associated with HA itself.
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Journal Title
Organic & Biomolecular Chemistry
Volume
10
Issue
1
Subject
Medicinal and biomolecular chemistry
Organic chemistry
Organic chemical synthesis