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3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations

dc.contributor.authorBanwell, Martin G
dc.contributor.authorCoster, Mark J
dc.contributor.authorHungerford, Natasha L
dc.contributor.authorGarson, Mary J
dc.contributor.authorSu, Stephen
dc.contributor.authorKotze, Andrew C
dc.contributor.authorMunro, Murray HG
dc.date.accessioned2017-05-03T15:16:54Z
dc.date.available2017-05-03T15:16:54Z
dc.date.issued2012
dc.date.modified2013-06-07T04:38:39Z
dc.identifier.issn1477-0520
dc.identifier.doi10.1039/C1OB06418E
dc.identifier.urihttp://hdl.handle.net/10072/48209
dc.description.abstractCompounds 2-5, incorporating various elements of the 3,4'-bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and certain derivatives. Screening of these compounds in various assays, including an ecological one, reveals that compound 5 exhibits allelochemical properties similar to those associated with HA itself.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom154
dc.relation.ispartofpageto161
dc.relation.ispartofissue1
dc.relation.ispartofjournalOrganic & Biomolecular Chemistry
dc.relation.ispartofvolume10
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchOrganic chemical synthesis
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode340503
dc.title3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorCoster, Mark J.
gro.griffith.authorHungerford, Natasha L.


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