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dc.contributor.authorNicholson, Daviden_US
dc.contributor.authorC. Kerr, Emmaen_US
dc.contributor.authorJepps, Owenen_US
dc.contributor.authorB. Nicholson, Lindsayen_US
dc.date.accessioned2017-04-24T11:13:22Z
dc.date.available2017-04-24T11:13:22Z
dc.date.issued2012en_US
dc.date.modified2013-06-07T04:17:47Z
dc.identifier.issn10233830en_US
dc.identifier.doi10.1007/s00011-012-0469-zen_US
dc.identifier.urihttp://hdl.handle.net/10072/48210
dc.description.abstractObjective and design A mathematical analysis of leukocytes accumulating in experimental autoimmune uveitis (EAU), using ordinary differential equations (ODEs) and incorporating a barrier to cell traffic. Materials and subjects Data from an analysis of the kinetics of cell accumulation within the eye during EAU. Methods We applied a well-established mathematical approach that uses ODEs to describe the behaviour of cells on both sides of the blood-retinal barrier and compared data from the mathematical model with experimental data from animals with EAU. Results The presence of the barrier is critical to the ability of the model to qualitatively reproduce the experimental data. However, barrier breakdown is not sufficient to produce a surge of cells into the eye, which depends also on asymmetry in the rates at which cells can penetrate the barrier. Antigen-presenting cell (APC) generation also plays a critical role and we can derive from the model the ratio for APC production under inflammatory conditions relative to production in the resting state, which has a value that agrees closely with that found by experiment. Conclusions Asymmetric trafficking and the dynamics of APC production play an important role in the dynamics of cell accumulation in EAU.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherSpringeren_US
dc.publisher.placeSwitzerlanden_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom759en_US
dc.relation.ispartofpageto773en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalInflammation Researchen_US
dc.relation.ispartofvolume61en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchBiological Mathematicsen_US
dc.subject.fieldofresearchCellular Interactions (incl. Adhesion, Matrix, Cell Wall)en_US
dc.subject.fieldofresearchAutoimmunityen_US
dc.subject.fieldofresearchcode010202en_US
dc.subject.fieldofresearchcode060106en_US
dc.subject.fieldofresearchcode110703en_US
dc.titleModelling experimental uveitis: barrier effects in autoimmune diseaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2012
gro.hasfulltextNo Full Text


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