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  • Synthesis of Novel gluco- and galacto-Functionalized Platinum Complexes

    Author(s)
    Moeker, Janina
    Thiem, Joachim
    Griffith University Author(s)
    Moeker, Janina
    Year published
    2009
    Metadata
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    Abstract
    Cisplatin, carboplatin, oxaliplatin and further derivatives are worldwide established cytostatics for the treatment of a vast range of tumours. These drugs showed extraordinary success; however, side effects and primary or developed secondary resistance of tumour cells represent severe problems, which prompt the development of novel functionalized platinum complexes. Selectively protected monohydroxy derivatives of glucose and galactose could be etherified by ?-halo ethers. Further, Finkelstein reaction and malonate synthesis gave precursor glycoconjugates which were easily transformed into their (diammine)platinum complexes. ...
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    Cisplatin, carboplatin, oxaliplatin and further derivatives are worldwide established cytostatics for the treatment of a vast range of tumours. These drugs showed extraordinary success; however, side effects and primary or developed secondary resistance of tumour cells represent severe problems, which prompt the development of novel functionalized platinum complexes. Selectively protected monohydroxy derivatives of glucose and galactose could be etherified by ?-halo ethers. Further, Finkelstein reaction and malonate synthesis gave precursor glycoconjugates which were easily transformed into their (diammine)platinum complexes. First tests with different tumour cell lines show biological activity of the gluco-functionalized platinum complex.(頗iley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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    Journal Title
    European Journal of Organic Chemistry
    Volume
    2009
    Issue
    28
    DOI
    https://doi.org/10.1002/ejoc.200900691
    Subject
    Organic Chemical Synthesis
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Publication URI
    http://hdl.handle.net/10072/48257
    Collection
    • Journal articles

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