Synthesis of Novel gluco- and galacto-Functionalized Platinum Complexes
Author(s)
Moeker, Janina
Thiem, Joachim
Griffith University Author(s)
Year published
2009
Metadata
Show full item recordAbstract
Cisplatin, carboplatin, oxaliplatin and further derivatives are worldwide established cytostatics for the treatment of a vast range of tumours. These drugs showed extraordinary success; however, side effects and primary or developed secondary resistance of tumour cells represent severe problems, which prompt the development of novel functionalized platinum complexes. Selectively protected monohydroxy derivatives of glucose and galactose could be etherified by ?-halo ethers. Further, Finkelstein reaction and malonate synthesis gave precursor glycoconjugates which were easily transformed into their (diammine)platinum complexes. ...
View more >Cisplatin, carboplatin, oxaliplatin and further derivatives are worldwide established cytostatics for the treatment of a vast range of tumours. These drugs showed extraordinary success; however, side effects and primary or developed secondary resistance of tumour cells represent severe problems, which prompt the development of novel functionalized platinum complexes. Selectively protected monohydroxy derivatives of glucose and galactose could be etherified by ?-halo ethers. Further, Finkelstein reaction and malonate synthesis gave precursor glycoconjugates which were easily transformed into their (diammine)platinum complexes. First tests with different tumour cell lines show biological activity of the gluco-functionalized platinum complex.(頗iley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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View more >Cisplatin, carboplatin, oxaliplatin and further derivatives are worldwide established cytostatics for the treatment of a vast range of tumours. These drugs showed extraordinary success; however, side effects and primary or developed secondary resistance of tumour cells represent severe problems, which prompt the development of novel functionalized platinum complexes. Selectively protected monohydroxy derivatives of glucose and galactose could be etherified by ?-halo ethers. Further, Finkelstein reaction and malonate synthesis gave precursor glycoconjugates which were easily transformed into their (diammine)platinum complexes. First tests with different tumour cell lines show biological activity of the gluco-functionalized platinum complex.(頗iley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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Journal Title
European Journal of Organic Chemistry
Volume
2009
Issue
28
Subject
Organic Chemical Synthesis
Medicinal and Biomolecular Chemistry
Organic Chemistry