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dc.contributor.authorMoeker, Janina
dc.contributor.authorThiem, Joachim
dc.date.accessioned2017-05-03T16:03:56Z
dc.date.available2017-05-03T16:03:56Z
dc.date.issued2009
dc.date.modified2013-06-07T00:32:28Z
dc.identifier.issn10990690
dc.identifier.doi10.1002/ejoc.200900691
dc.identifier.urihttp://hdl.handle.net/10072/48257
dc.description.abstractCisplatin, carboplatin, oxaliplatin and further derivatives are worldwide established cytostatics for the treatment of a vast range of tumours. These drugs showed extraordinary success; however, side effects and primary or developed secondary resistance of tumour cells represent severe problems, which prompt the development of novel functionalized platinum complexes. Selectively protected monohydroxy derivatives of glucose and galactose could be etherified by ?-halo ethers. Further, Finkelstein reaction and malonate synthesis gave precursor glycoconjugates which were easily transformed into their (diammine)platinum complexes. First tests with different tumour cell lines show biological activity of the gluco-functionalized platinum complex.(頗iley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom4842
dc.relation.ispartofpageto4847
dc.relation.ispartofissue28
dc.relation.ispartofjournalEuropean Journal of Organic Chemistry
dc.relation.ispartofvolume2009
dc.rights.retentionY
dc.subject.fieldofresearchOrganic Chemical Synthesis
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchcode030503
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.titleSynthesis of Novel gluco- and galacto-Functionalized Platinum Complexes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorMoeker, Janina


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