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dc.contributor.authorLea, Rodney
dc.contributor.authorOvcaric, Micky
dc.contributor.authorSundholm, James
dc.contributor.authorSolyom, Leah
dc.contributor.authorMacMillan, John
dc.contributor.authorGriffiths, Lyn
dc.contributor.editorDr. James I Morgan, Floyd E Bloom
dc.date.accessioned2017-05-03T12:15:56Z
dc.date.available2017-05-03T12:15:56Z
dc.date.issued2005
dc.date.modified2009-01-23T05:38:48Z
dc.identifier.issn0169328X
dc.identifier.doi10.1016/j.molbrainres.2005.01.006
dc.identifier.urihttp://hdl.handle.net/10072/4828
dc.description.abstractMigraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that is likely to be influenced by multiple genes some of which may be capable of causing vascular changes leading to disease onset. This study was conducted to determine whether the ACE I/D gene variant is involved in migraine risk and whether this variant might act in combination with the previously implicated MTHFR C677T genetic variant in 270 migraine cases and 270 matched controls. Statistical analysis of the ACE I/D variant indicated no significant difference in allele or genotype frequencies (P > 0.05). However, grouping of genotypes showed a modest, yet significant, over-representation of the DD/ID genotype in the migraine group (88%) compared to controls (81%) (OR of 1.64, 95% CI: 1.00-2.69, P = 0.048). Multivariate analysis, including genotype data for the MTHFR C677T, provided evidence that the MTHFR (TT) and ACE (ID/DD) genotypes act in combination to increase migraine susceptibility (OR = 2.18, 95% CI: 1.15-4.16, P = 0.018). This effect was greatest for the MA subtype where the genotype combination corresponded to an OR of 2.89 (95% CI:1.47-5.72, P = 0.002). In Caucasians, the ACE D allele confers a weak independent risk to migraine susceptibility and also appears to act in combination with the C677T variant in the MTHFR gene to confer a stronger influence on the disease.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.publisher.urihttp://www.sciencedirect.com/science/journal/0169328X
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom112
dc.relation.ispartofpageto117
dc.relation.ispartofjournalMolecular Brain Research
dc.relation.ispartofvolume136
dc.rights.retentionN
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1701
dc.subject.fieldofresearchcode1702
dc.titleGenetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorMacMillan, John C.
gro.griffith.authorSundholm, James R.
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorLea, Rodney A.
gro.griffith.authorOvcaric, Micky
gro.griffith.authorSolyom, Leah


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