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dc.contributor.authorColson, Natalieen_US
dc.contributor.authorLea, Rodneyen_US
dc.contributor.authorQuinlan, Sharonen_US
dc.contributor.authorMacMillan, Johnen_US
dc.contributor.authorGriffiths, Lynen_US
dc.contributor.editorDr. James R Lupski, Dr. Manuel B Graeber, Dr. Ulrich Mülleren_US
dc.date.accessioned2017-04-24T09:13:50Z
dc.date.available2017-04-24T09:13:50Z
dc.date.issued2005en_US
dc.date.modified2010-08-20T06:24:53Z
dc.identifier.issn13646745en_US
dc.identifier.doi10.1007/s10048-004-0205-0en_AU
dc.identifier.urihttp://hdl.handle.net/10072/4832
dc.description.abstractMigraine is a common neurological condition with a complex mode of inheritance. Steroid hormones have long been implicated in migraine, although their role remains unclear. Our investigation considered that genes involved in hormonal pathways may play a role in migraine susceptibility. We therefore investigated the androgen receptor (AR) CAG repeat, and the progesterone receptor (PR) PROGINS insert by cross-sectional association analysis. The results showed no association with the AR CAG repeat in our study group of 275 migraineurs and 275 unrelated controls. Results of the PR PROGINS analysis showed a significant difference in the same cohort, and in an independent follow-up study population of 300 migraineurs and 300 unrelated controls. Analysis of the genotypic risk groups of both populations together indicated that individuals who carried the PROGINS insert were 1.8 times more likely to suffer migraine. Interaction analysis of the PROGINS variant with our previously reported associated ESR1 594A variant showed that individuals who possessed at least one copy of both risk alleles were 3.2 times more likely to suffer migraine. Hence, variants of these steroid hormone receptor genes appear to act synergistically to increase the risk of migraine by a factor of three.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringer-Verlag GmbHen_US
dc.publisher.placeGermanyen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom17en_US
dc.relation.ispartofpageto23en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalNeurogeneticsen_US
dc.relation.ispartofvolume6en_US
dc.rights.retentionNen_AU
dc.subject.fieldofresearchcode270210en_US
dc.titleInvestigation of hormone receptor genes in migraineen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.date.issued2005
gro.hasfulltextNo Full Text


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