Guiding principles for natural product drug discovery
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Natural products (NPs) have historically been a fertile source of new drugs for the pharmaceutical industry. However, this once-popular approach has waned considerably over the past two decades as the high-throughput screening of megalibraries comprised mainly of molecules with non-natural (synthetic) motifs has unfolded. Contemporary high-throughput screening libraries contain molecules compliant with physicochemical profiles considered essential for downstream development. Until recently, there was no strategy that aligned NP screening with the same physicochemical profiles. An approach based on Log P has addressed these concerns and, together with advances in isolation, afforded NP leads in timelines compatible with pure compound screening. Concomitant progress related to access of biological resources has provided long-awaited legal certainty to further facilitate NP drug discovery.
Future Medicinal Chemistry
Copyright 2012 Future Science. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. For full bibliographic citation, please refer to the version available at www.future-science.com.
Medicinal and Biomolecular Chemistry not elsewhere classified