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dc.contributor.authorCamp, Daviden_US
dc.contributor.authorDavis, Rohanen_US
dc.contributor.authorA. Evans-Illidge, Elizabethen_US
dc.contributor.authorQuinn, Ronalden_US
dc.date.accessioned2017-05-03T11:30:47Z
dc.date.available2017-05-03T11:30:47Z
dc.date.issued2012en_US
dc.date.modified2014-04-22T05:24:10Z
dc.identifier.issn1756-8919en_US
dc.identifier.doi10.4155/fmc.12.55en_US
dc.identifier.urihttp://hdl.handle.net/10072/48359
dc.description.abstractNatural products (NPs) have historically been a fertile source of new drugs for the pharmaceutical industry. However, this once-popular approach has waned considerably over the past two decades as the high-throughput screening of megalibraries comprised mainly of molecules with non-natural (synthetic) motifs has unfolded. Contemporary high-throughput screening libraries contain molecules compliant with physicochemical profiles considered essential for downstream development. Until recently, there was no strategy that aligned NP screening with the same physicochemical profiles. An approach based on Log P has addressed these concerns and, together with advances in isolation, afforded NP leads in timelines compatible with pure compound screening. Concomitant progress related to access of biological resources has provided long-awaited legal certainty to further facilitate NP drug discovery.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent844333 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherFuture Scienceen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom1067en_US
dc.relation.ispartofpageto1084en_US
dc.relation.ispartofissue9en_US
dc.relation.ispartofjournalFuture Medicinal Chemistryen_US
dc.relation.ispartofvolume4en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classifieden_US
dc.subject.fieldofresearchcode030499en_US
dc.titleGuiding principles for natural product drug discoveryen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2012 Future Science. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. For full bibliographic citation, please refer to the version available at www.future-science.com.en_US
gro.date.issued2012
gro.hasfulltextFull Text


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