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dc.contributor.authorHaywood, A
dc.contributor.authorMangan, M
dc.contributor.authorGrant, G
dc.contributor.authorGlass, B
dc.contributor.editorProfessor Shane Scott
dc.date.accessioned2017-05-03T14:23:15Z
dc.date.available2017-05-03T14:23:15Z
dc.date.issued2005
dc.date.modified2009-10-14T22:14:07Z
dc.identifier.issn1445-937X
dc.identifier.doi10.1002/j.2055-2335.2005.tb00333.x
dc.identifier.urihttp://hdl.handle.net/10072/4835
dc.description.abstractBackground: Isoniazid mixtures are compounded in Australia using commercially available isoniazid tablets. Aim: To determine the stability of isoniazid 10 mg/mL mixture compounded from commercially available isoniazid tablets. Method: The stability of the compounded isoniazid mixture stored at a range of temperatures (4-60 é was assessed with high performance liquid chromatography. Differential scanning calorimetry was used to investigate the compatibility of isoniazid with the excipient, lactose. Results: The compounded isoniazid mixture exhibited significant degradation (= 10% after 3 days at 4 and 25 ꃩ, whereas the control (using isoniazid powder) retained desired stability (> 90% at 30 days) under identical conditions. A replicate control formulation, spiked with lactose, produced statistically similar degradation profiles to that of the compounded isoniazid mixture (p > 0.05), indicating lactose to be responsible for the degradation of isoniazid. The thermoanalytical studies demonstrated an incompatibility between isoniazid and lactose (broadening and shifting of melting endotherm of isoniazid at 171.46 ꃩ. Conclusion: The British Pharmaceutical Codex specifies the use of isoniazid powder for compounding isoniazid mixture. This study highlights the importance for stability evaluations on all modified extemporaneous preparations in order to ensure that quality pharmaceuticals are delivered to patients.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent522721 bytes
dc.format.extent13863 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.languageEnglish
dc.language.isoeng
dc.publisherThe Society of Hospital Pharmacists of Australia
dc.publisher.placeCollingwood, VIC, Australia
dc.publisher.urihttps://onlinelibrary.wiley.com/doi/10.1002/j.2055-2335.2005.tb00333.x
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom181
dc.relation.ispartofpageto182
dc.relation.ispartofeditionSeptember 2005
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Pharmacy Practice and Research
dc.relation.ispartofvolume35
dc.rights.retentionY
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3214
dc.titleExtemporaneous Isoniazid Mixture: Stability Implications
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Pharmacy
gro.rights.copyright© 2005 Journal of Pharmacy Practice and Research. The attached file is reproduced here in accordance with the copyright policy of the publisher.
gro.date.issued2005
gro.hasfulltextFull Text
gro.griffith.authorHaywood, Alison
gro.griffith.authorGrant, Gary D.


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