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  • Ianthelliformisamines A−C, Antibacterial Bromotyrosine-Derived Metabolites from the Marine Sponge Suberea ianthelliformis

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    Accepted Manuscript (AM)
    Author(s)
    Xu, Min
    Davis, Rohan A
    Feng, Yunjiang
    Sykes, Melissa L
    Shelper, Todd
    Avery, Vicky M
    Camp, David
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Davis, Rohan A.
    Sykes, Melissa L.
    Avery, Vicky M.
    Feng, Yun J.
    Year published
    2012
    Metadata
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    Abstract
    A high-throughput screening campaign using a prefractionated natural product library and an in vitro Pseudomonas aeruginosa (PAO200 strain) assay identified two antibacterial fractions derived from the marine sponge Suberea ianthelliformis. Mass-directed isolation of the CH2Cl2/CH3OH extract from S. ianthelliformis resulted in the purification of three new bromotyrosine-derived metabolites, ianthelliformisamines A–C (1–3), together with the known natural products aplysamine 1 (4) and araplysillin I (5). The structures of 1–3 were determined following analysis of 1D and 2D NMR and MS spectroscopic data. This is the first ...
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    A high-throughput screening campaign using a prefractionated natural product library and an in vitro Pseudomonas aeruginosa (PAO200 strain) assay identified two antibacterial fractions derived from the marine sponge Suberea ianthelliformis. Mass-directed isolation of the CH2Cl2/CH3OH extract from S. ianthelliformis resulted in the purification of three new bromotyrosine-derived metabolites, ianthelliformisamines A–C (1–3), together with the known natural products aplysamine 1 (4) and araplysillin I (5). The structures of 1–3 were determined following analysis of 1D and 2D NMR and MS spectroscopic data. This is the first report of chemistry from the marine sponge S. ianthelliformis. Ianthelliformisamine A (1) showed inhibitory activity against the Gram-negative bacterium P. aeruginosa with an IC50 value of 6.8 μM (MIC = 35 μM).
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    Journal Title
    Journal of Natural Products
    Volume
    75
    Issue
    5
    DOI
    https://doi.org/10.1021/np300147d
    Copyright Statement
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright 2012 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/np300147d
    Subject
    Chemical sciences
    Medicinal and biomolecular chemistry not elsewhere classified
    Biological sciences
    Biomedical and clinical sciences
    Traditional, complementary and integrative medicine
    Publication URI
    http://hdl.handle.net/10072/48360
    Collection
    • Journal articles

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