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dc.contributor.authorAnissimov, Yuri G
dc.contributor.authorZhao, Xin
dc.contributor.authorRoberts, Michael S
dc.contributor.authorZvyagin, Andrei V
dc.date.accessioned2017-05-03T15:13:57Z
dc.date.available2017-05-03T15:13:57Z
dc.date.issued2012
dc.date.modified2013-06-18T02:36:19Z
dc.identifier.issn0378-5173
dc.identifier.doi10.1016/j.ijpharm.2012.01.055
dc.identifier.urihttp://hdl.handle.net/10072/48461
dc.description.abstractFluorescence recovery after photo-bleaching experiments were performed in human stratum corneum in vitro. Fluorescence multiphoton tomography was used, which allowed the dimensions of the photobleached volume to be at the micron scale and located fully within the lipid phase of the stratum corneum. Analysis of the fluorescence recovery data with simplified mathematical models yielded the diffusion coefficient of small molecular weight organic fluorescent dye Rhodamine B in the stratum corneum lipid phase of about (3-6)x10(-9)cm(2)s(-1). It was concluded that the presented method can be used for detailed analysis of localised diffusion coefficients in the stratum corneum phases for various fluorescent probes.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1466032 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom93
dc.relation.ispartofpageto97
dc.relation.ispartofjournalInternational Journal of Pharmaceutics
dc.relation.ispartofvolume435
dc.rights.retentionY
dc.subject.fieldofresearchBiological mathematics
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmaceutical sciences
dc.subject.fieldofresearchcode490102
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321405
dc.titleFluorescence recovery after photo-bleaching as a method to determine local diffusion coefficient in the stratum corneum
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2012 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorAnissimov, Yuri G.


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