Metachronous carcinomas in colorectum and its clinicopathological significance
MetadataShow full item record
Purpose The study was designed to examine the significance of colorectal metachronous carcinoma in a large cohort of patients. Methods Over a mean follow-up period of 10 years, the clinicopathological features, microsatellite instability (MSI) and clinical follow-up of 56 patients with metachronous colorectal carcinoma were analysed. Results The prevalence of metachronous colorectal carcinoma was 2.1 %. The metachronous colorectal carcinomas appeared between 7 and 246 months (mean066 months) after surgical resection of the index colorectal carcinomas. Thirty-six per cent (n020) of the metachronous carcinoma occurred more than 5 years after the operation of the index carcinoma. Of the 56 patients, 20 % (n011) of the metachronous colorectal carcinomas were mucinous adenocarcinoma. Cancers detected in the secondary operations (metachronous colorectal carcinomas), when compared with the primary index cancers, were smaller, showed higher proportions of mucinous adenocarcinoma and more often located in the proximal colon. Patients with metachronous colorectal cancers had higher prevalence of mucinous adenocarcinoma, loss of staining for MSI markers and better survival rates than other patients with colorectal cancers. Conclusions Patients with metachronous colorectal carcinomas have characteristic features, and attention to these features is important for better management of this group of cancer.
International Journal of Colorectal Disease
© 2012 Springer Berlin / Heidelberg. This is an electronic version of an article published in International Journal of Colorectal Disease, October 2012, Volume 27, Issue 10, pp 1303-1310. International Journal of Colorectal Disease is available online at: http://link.springer.com/ with the open URL of your article.
Medical and Health Sciences not elsewhere classified