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dc.contributor.authorNikbakht, Mahdi
dc.contributor.authorShabanizadeh, Ahmad
dc.contributor.authorSalehi, Mansour
dc.contributor.authorTalebi, Ardeshir
dc.contributor.authorArababadi, Mohammad Kazemi
dc.contributor.authorDahim, Hajar
dc.contributor.authorKennedy, Derek
dc.date.accessioned2017-05-16T12:30:27Z
dc.date.available2017-05-16T12:30:27Z
dc.date.issued2012
dc.date.modified2013-06-14T00:38:58Z
dc.identifier.issn0007-5027
dc.identifier.doi10.1309/LM36TEMLUWNZJ0TZ
dc.identifier.urihttp://hdl.handle.net/10072/48482
dc.description.abstractObjective: To evaluate the methylation status of the breast cancer 1, early onset (BRCA1) promoter in ovarian cancer in Iranian patients. Methods: The BRCA1 promoter methylation status of tissue from 60 patients with M쬬erian-type ovarian cancer and matched benign ovarian tissue from the same patients was evaluated using bisulfate-modified DNA in methylation-specific polymerase chain reaction (MSP CR) assays. Results: Analysis of BRCA1 promoter methylation status showed that 8 of 60 cases (13%) were methylated and 11 of 60 cases (18%) were unmethylated. Conclusion: Methylation of the BRCA1 promoter may be a risk factor or cause of ovarian cancer.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Clinical Pathology
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom18
dc.relation.ispartofpageto21
dc.relation.ispartofissue4
dc.relation.ispartofjournalLaboratory Medicine
dc.relation.ispartofvolume43
dc.rights.retentionY
dc.subject.fieldofresearchMedical Genetics (excl. Cancer Genetics)
dc.subject.fieldofresearchcode110311
dc.titleBRCA1 Promoter Methylation Status in Ovarian Cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorKennedy, Derek D.


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