| dc.contributor.author | Nikbakht, Mahdi | |
| dc.contributor.author | Shabanizadeh, Ahmad | |
| dc.contributor.author | Salehi, Mansour | |
| dc.contributor.author | Talebi, Ardeshir | |
| dc.contributor.author | Arababadi, Mohammad Kazemi | |
| dc.contributor.author | Dahim, Hajar | |
| dc.contributor.author | Kennedy, Derek | |
| dc.date.accessioned | 2017-05-16T12:30:27Z | |
| dc.date.available | 2017-05-16T12:30:27Z | |
| dc.date.issued | 2012 | |
| dc.date.modified | 2013-06-14T00:38:58Z | |
| dc.identifier.issn | 0007-5027 | |
| dc.identifier.doi | 10.1309/LM36TEMLUWNZJ0TZ | |
| dc.identifier.uri | http://hdl.handle.net/10072/48482 | |
| dc.description.abstract | Objective: To evaluate the methylation status of the breast cancer 1, early onset (BRCA1) promoter in ovarian cancer in Iranian patients. Methods: The BRCA1 promoter methylation status of tissue from 60 patients with M쬬erian-type ovarian cancer and matched benign ovarian tissue from the same patients was evaluated using bisulfate-modified DNA in methylation-specific polymerase chain reaction (MSP CR) assays. Results: Analysis of BRCA1 promoter methylation status showed that 8 of 60 cases (13%) were methylated and 11 of 60 cases (18%) were unmethylated. Conclusion: Methylation of the BRCA1 promoter may be a risk factor or cause of ovarian cancer. | |
| dc.description.peerreviewed | Yes | |
| dc.description.publicationstatus | Yes | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | American Society for Clinical Pathology | |
| dc.publisher.place | United States | |
| dc.relation.ispartofstudentpublication | N | |
| dc.relation.ispartofpagefrom | 18 | |
| dc.relation.ispartofpageto | 21 | |
| dc.relation.ispartofissue | 4 | |
| dc.relation.ispartofjournal | Laboratory Medicine | |
| dc.relation.ispartofvolume | 43 | |
| dc.rights.retention | Y | |
| dc.subject.fieldofresearch | Medical Genetics (excl. Cancer Genetics) | |
| dc.subject.fieldofresearchcode | 110311 | |
| dc.title | BRCA1 Promoter Methylation Status in Ovarian Cancer | |
| dc.type | Journal article | |
| dc.type.description | C1 - Articles | |
| dc.type.code | C - Journal Articles | |
| gro.rights.copyright | Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information. | |
| gro.date.issued | 2012 | |
| gro.hasfulltext | No Full Text | |
| gro.griffith.author | Kennedy, Derek D. | |
