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dc.contributor.authorWiden, Ceciliaen_US
dc.contributor.authorBarclay, Chrisen_US
dc.date.accessioned2017-05-03T11:40:00Z
dc.date.available2017-05-03T11:40:00Z
dc.date.issued2005en_US
dc.date.modified2010-08-19T07:04:46Z
dc.identifier.issn00316768en_US
dc.identifier.doi10.1007/s00424-005-1408-4en_AU
dc.identifier.urihttp://hdl.handle.net/10072/4848
dc.description.abstractThe aims of this study were to measure the resting metabolic rate of isolated mouse papillary muscles and to determine whether diffusive O2 supply is adequate to support the resting metabolism. Resting metabolism of left ventricular papillary muscles was measured in vitro (27C) using the myothermic technique. The rate of resting metabolism declined exponentially with time towards a steady value, with a time constant of 18+/-2 min (n=13). There was no alteration in isometric force output during this time. The magnitude of the resting metabolism, which depended inversely on muscle mass, more than doubled following a change in substrate from glucose to pyruvate and was increased 2.5-fold when the osmolarity of the bathing solution was increased by addition of 300 mM sucrose. Addition of 30 mM 2, 3-butanedione monoxime affected neither the time course of the decline in metabolic rate nor the eventual steady value. Analysis of the diffusive oxygen supply to the isolated preparation indicated that small papillary muscles (mass <1 mg), which have a very high resting metabolic rate early in an experiment, are unlikely to be adequately oxygenated.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringer-Verlagen_US
dc.publisher.placeBerlin, Germanyen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom209en_US
dc.relation.ispartofpageto216en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalPflugers Archiv: European Journal of Physiologyen_US
dc.relation.ispartofvolume450en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270602en_US
dc.titleResting metabolism of mouse papillary muscleen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Allied Health Sciencesen_US
gro.date.issued2005
gro.hasfulltextNo Full Text


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