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dc.contributor.authorBarclay, Chrisen_US
dc.date.accessioned2017-05-03T11:40:00Z
dc.date.available2017-05-03T11:40:00Z
dc.date.issued2005en_US
dc.date.modified2010-08-20T06:27:59Z
dc.identifier.issn01424319en_US
dc.identifier.doi10.1007/s10974-005-9013-xen_AU
dc.identifier.urihttp://hdl.handle.net/10072/4849
dc.description.abstractThe purpose of this study was to use A. V. Hill's equation describing diffusion of O2 into cylindrical muscles to assess the adequacy of O2 supply for commonly used isolated preparations of mammalian cardiac and skeletal muscles. The diffusion equation was solved numerically to give the maximum, steady state O2 diffusion distances (i.e. the distance from the surface of the muscle to the radial location where dO2/dr is 0) for both resting and contracting muscles and for a range of temperatures. Non-steady state solutions for the rest-to-work transition were also determined to estimate how long contractile activity could be continued before anoxia develops at the muscle centre. The influence on muscle oxygenation of myoglobin-facilitated O2 diffusion was also assessed. The analysis was performed for typical sized, whole muscles from adult rats and mice, for frog sartorius muscle and for a range of temperatures. Muscle O2 consumption rates were taken from the literature. The results indicated that (1) diffusive O2 supply would be adequate to support resting metabolism of soleus and EDL muscles of rat and mouse but may not be adequate to support the transient high resting metabolic rate of papillary muscles shortly after dissection, (2) during steady contractile activity of soleus and EDL muscles, particularly those from the rat, over a reasonable range of duty cycles, adequate O2 supply could only be ensured if the radii of preparations was substantially smaller than those of whole muscles and (3) for cardiac muscles, diffusive O2 supply could only support steady-state metabolism at twitch frequencies <1 Hz for whole papillary muscles from rat and <3 Hz for those from mouse. Reducing experimental temperature markedly enhances O2 supply to skeletal, but not cardiac, muscle. O2 supply from myoglobin had only minimal effects on oxygenation under typical isolated muscle conditions.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringer-Verlagen_US
dc.publisher.placeNetherlandsen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom225en_US
dc.relation.ispartofpageto235en_US
dc.relation.ispartofjournalJournal of Muscle Research and Cell Motilityen_US
dc.relation.ispartofvolume26en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270602en_US
dc.titleModelling diffusive O2 supply to isolated preparations of mammalian skeletal and cardiac muscleen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Rehabilitation Sciencesen_US
gro.date.issued2005
gro.hasfulltextNo Full Text


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