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dc.contributor.authorKidd, Lisa J
dc.contributor.authorCowling, Nick R
dc.contributor.authorWu, Andy C
dc.contributor.authorKelly, Wendy L
dc.contributor.authorForwood, Mark R
dc.date.accessioned2017-05-03T12:07:08Z
dc.date.available2017-05-03T12:07:08Z
dc.date.issued2013
dc.date.modified2014-08-28T23:00:08Z
dc.identifier.issn0736-0266
dc.identifier.doi10.1002/jor.22203
dc.identifier.urihttp://hdl.handle.net/10072/48510
dc.description.abstractAnti-inflammatory drugs are widely used to manage pain associated with stress fractures (SFxs), but little is known about their effects on healing of those injuries. We hypothesized that selective and non-selective anti-inflammatory treatments would retard the healing of SFx in the rat ulna. SFxs were created by cyclic loading of the ulna in Wistar rats. Ulnae were harvested 2, 4 or 6 weeks following loading. Rats were treated with non-selective NSAID, ibuprofen (30?mg/kg/day); selective COX-2 inhibition, [5,5-dimethyl-3-3 (3 fluorophenyl)-4-(4 methylsulfonal) phenyl-2 (5H)-furanone] (DFU) (2.0?mg/kg/day); or the novel c5a anatagonist PMX53 (10?mg/kg/day, 4 and 6 weeks only); with appropriate vehicle as control. Quantitative histomorphometric measurements of SFx healing were undertaken. Treatment with the selective COX-2 inhibitor, DFU, reduced the area of resorption along the fracture line at 2 weeks, without affecting bone formation at later stages. Treatment with the non-selective, NSAID, ibuprofen decreased both bone resorption and bone formation so that there was significantly reduced length and area of remodeling and lamellar bone formation within the remodeling unit at 6 weeks after fracture. The C5a receptor antagonist PMX53 had no effect on SFx healing at 4 or 6 weeks after loading, suggesting that PMX53 would not delay SFx healing. Both selective COX-2 inhibitors and non-selective NSAIDs have the potential to compromise SFx healing, and should be used with caution when SFx is diagnosed or suspected.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent207603 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom235
dc.relation.ispartofpageto242
dc.relation.ispartofissue2
dc.relation.ispartofjournalJournal of Orthopaedic Research
dc.relation.ispartofvolume31
dc.rights.retentionY
dc.subject.fieldofresearchOrthopaedics
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchHuman Movement and Sports Sciences
dc.subject.fieldofresearchcode110314
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1106
dc.titleSelective and Non-Selective Cyclooxygenase Inhibitors Delay Stress Fracture Healing in the Rat Ulna
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2012 Blackwell Publishing. This is a preprint of an article published in the Journal of Orthopaedic Research. The definitive version is available at http://onlinelibrary.wiley.com/
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorForwood, Mark R.
gro.griffith.authorKelly, Wendy L.
gro.griffith.authorWu, Andy C.


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