dc.contributor.author | Bhatt, Beenu | |
dc.contributor.author | Boehm, Raphael | |
dc.contributor.author | Kerry, Philip S | |
dc.contributor.author | Dyason, Jeffrey C | |
dc.contributor.author | Russell, Rupert JM | |
dc.contributor.author | Thomson, Robin J | |
dc.contributor.author | von Itzstein, Mark | |
dc.date.accessioned | 2017-05-03T15:55:50Z | |
dc.date.available | 2017-05-03T15:55:50Z | |
dc.date.issued | 2012 | |
dc.date.modified | 2013-06-17T03:03:02Z | |
dc.identifier.issn | 0022-2623 | |
dc.identifier.doi | 10.1021/jm301145k | |
dc.identifier.uri | http://hdl.handle.net/10072/48670 | |
dc.description.abstract | A series of C3 O-functionalized 2-acetamido-2-deoxy-?4-߭D-glucuronides were synthesized to explore noncharge interactions in subsite 2 of the in?uenza virus sialidase active site. In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solution conformation to bind with all substituents well positioned in the active site. The parent compound inhibits in?uenza virus sialidase at a sub-占level; the introduction of small alkyl substituents or an acetyl group at C3 is also tolerated. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 8963 | |
dc.relation.ispartofpageto | 8968 | |
dc.relation.ispartofissue | 20 | |
dc.relation.ispartofjournal | Journal of Medicinal Chemistry | |
dc.relation.ispartofvolume | 55 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Biomolecular modelling and design | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Organic chemical synthesis | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 340402 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 340503 | |
dc.subject.fieldofresearchcode | 3214 | |
dc.title | Exploring the Interactions of Unsaturated Glucuronides with Influenza Virus Sialidase | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Office of the Snr Dep Vice Chancellor, Institute for Glycomics | |
gro.rights.copyright | Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information. | |
gro.date.issued | 2012 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | von Itzstein, Mark | |
gro.griffith.author | Thomson, Robin J. | |