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dc.contributor.authorBhatt, Beenu
dc.contributor.authorBoehm, Raphael
dc.contributor.authorKerry, Philip S
dc.contributor.authorDyason, Jeffrey C
dc.contributor.authorRussell, Rupert JM
dc.contributor.authorThomson, Robin J
dc.contributor.authorvon Itzstein, Mark
dc.date.accessioned2017-05-03T15:55:50Z
dc.date.available2017-05-03T15:55:50Z
dc.date.issued2012
dc.date.modified2013-06-17T03:03:02Z
dc.identifier.issn0022-2623
dc.identifier.doi10.1021/jm301145k
dc.identifier.urihttp://hdl.handle.net/10072/48670
dc.description.abstractA series of C3 O-functionalized 2-acetamido-2-deoxy-?4-߭D-glucuronides were synthesized to explore noncharge interactions in subsite 2 of the in?uenza virus sialidase active site. In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solution conformation to bind with all substituents well positioned in the active site. The parent compound inhibits in?uenza virus sialidase at a sub-占level; the introduction of small alkyl substituents or an acetyl group at C3 is also tolerated.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom8963
dc.relation.ispartofpageto8968
dc.relation.ispartofissue20
dc.relation.ispartofjournalJournal of Medicinal Chemistry
dc.relation.ispartofvolume55
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiomolecular modelling and design
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchOrganic chemical synthesis
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340402
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode340503
dc.subject.fieldofresearchcode3214
dc.titleExploring the Interactions of Unsaturated Glucuronides with Influenza Virus Sialidase
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorThomson, Robin J.


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