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dc.contributor.authorEbert, Jay R
dc.contributor.authorFallon, Michael
dc.contributor.authorRobertson, William B
dc.contributor.authorLloyd, David G
dc.contributor.authorZheng, MH
dc.contributor.authorWood, David J
dc.contributor.authorAckland, Timothy
dc.date.accessioned2017-05-03T15:57:10Z
dc.date.available2017-05-03T15:57:10Z
dc.date.issued2011
dc.date.modified2013-02-13T23:45:35Z
dc.identifier.issn1947-6035
dc.identifier.doi10.1177/1947603510380902
dc.identifier.urihttp://hdl.handle.net/10072/49071
dc.description.abstractObjective: To assess the safety and efficacy of accelerated compared with traditional postoperative weightbearing (WB) rehabilitation following matrix-induced autologous chondrocyte implantation (MACI) of the knee, using MRI. Methods: A randomized controlled study design was used to assess MRI-based outcomes of MACI grafts in 70 patients (45 men, 25 women) who underwent MACI to the medial or lateral femoral condyle, in combination with either traditional or accelerated approaches to postoperative WB rehabilitation. High-resolution MRI was undertaken and assessed 8 previously defined pertinent parameters of graft repair, as well as a combined MRI composite score at 3, 12, and 24 months postsurgery. The association between clinical and MRI-based outcomes, patient demographics, chondral defect parameters, and injury/ surgery history was investigated. Results: Both groups significantly improved (P < 0.05) in the MRI composite score and pertinent descriptors of graft repair throughout the postoperative period until 24 months postsurgery. There were no differences (P > 0.05) observed between the 2 groups. Patient age, body mass index, chondral defect size, and duration of preoperative symptoms were significantly correlated (P < 0.05) with several MRI-based outcomes at 24 months, whereas there were no significant pertinent correlations (P > 0.05) observed between clinical and MRI-based outcomes. Conclusion: The accelerated WB approach was not detrimental to graft development at any stage throughout the postoperative assessment timeline from baseline to 24 months postsurgery and may potentially accelerate patient return to normal function, while reducing postoperative muscle loss, intra-articular adhesions, and associated gait abnormalities.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSage
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom60
dc.relation.ispartofpageto72
dc.relation.ispartofissue1
dc.relation.ispartofjournalCartilage
dc.relation.ispartofvolume2
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchMedical biotechnology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOrthopaedics
dc.subject.fieldofresearchBiomechanics
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode3206
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320216
dc.subject.fieldofresearchcode420701
dc.titleRadiological Assessment of Accelerated versus Traditional Approaches to Postoperative Rehabilitation following Matrix-Induced Autologous Chondrocyte Implantation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorLloyd, David


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