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  • Benefits of Genetic Algorithm Feature-Based Resampling for Protein Structure Prediction

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    Author(s)
    Higgs, Trent
    Stantic, Bela
    Hoque, Tamjidul
    Sattar, Abdul
    Griffith University Author(s)
    Stantic, Bela
    Sattar, Abdul
    Year published
    2012
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    Abstract
    Protein structure prediction (PSP) is an important task as the three-dimensional structure of a protein dictates what function it performs. PSP can be modelled on computers by searching for the global free energy minimum based on Afinsen's 'Thermodynamic Hypothesis'. To explore this free energy landscape Monte Carlo (MC) based search algorithms have been heavily utilised in the literature. However, evolutionary search approaches, like Genetic Algorithms (GA), have shown a lot of potential in low-resolution models to produce more accurate predictions. In this paper we have evaluated a GA feature-based resampling approach, ...
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    Protein structure prediction (PSP) is an important task as the three-dimensional structure of a protein dictates what function it performs. PSP can be modelled on computers by searching for the global free energy minimum based on Afinsen's 'Thermodynamic Hypothesis'. To explore this free energy landscape Monte Carlo (MC) based search algorithms have been heavily utilised in the literature. However, evolutionary search approaches, like Genetic Algorithms (GA), have shown a lot of potential in low-resolution models to produce more accurate predictions. In this paper we have evaluated a GA feature-based resampling approach, which uses a heavy-atom based model, by selecting 17 random CASP 8 sequences and evaluating it against two different MC approaches. Our results indicate that our GA improves both its root mean square deviation (RMSD) and template modelling score (TM-Score). From our analysis we can conclude that by combining feature-based resampling with Genetic Algorithms we can create structures with more native-like features due to the use of crossover and mutation operators, which is supported by the low RMSD values we obtained.
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    Conference Title
    BIOINFORMATICS: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON BIOINFORMATICS MODELS, METHODS AND ALGORITHMS
    Publisher URI
    http://www.bioinformatics.biostec.org/BIOINFORMATICS2012/
    Copyright Statement
    © 2012 Springer Berlin/Heidelberg. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher.The original publication is available at www.springerlink.com
    Subject
    Modelling and simulation
    Publication URI
    http://hdl.handle.net/10072/49193
    Collection
    • Conference outputs

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