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dc.contributor.authorBerners-Price, Sue
dc.contributor.authorBowen, Richard
dc.contributor.authorFernandes, Manuel A.
dc.contributor.authorLayh, Marcus
dc.contributor.authorLesueur, William
dc.contributor.authorMahepal, Sherika
dc.contributor.authorMtotywa, Matolwandile M.
dc.contributor.authorSue, Rodney E.
dc.contributor.authorvan Rensburge, Constance E. J.
dc.description.abstractThe 2:1 and 1:2 adducts of Au(I) and 1:2 adducts of Ag(I) with the diphosphine 2,3-bis(diphenylphosphino)maleic acid (dpmaa) have been prepared in high yields. Crystal structures have been determined for the neutral digold complex (AuCl)2(dpmaa) 砲thf (1) and the bis-chelated complex [Au(dpmaa)2]Cl 砈2O 砃H3OH (2). For 1, conformational rigidity imposed by the ethylenic bridge facilitates the formation of short intramolecular Au-Au contacts with no evidence of similar intermolecular contacts. Complex 2 crystallizes with [Au(dpmaa)2]+ cations hydrogen bonded through the carboxyl groups to a water molecule and chloride anion to form a H-bonded chain along the a axis. 31P NMR titration of 1 with dpmaa in acetone shows conversion to 2 at Au:P-P ratios less than 1:1 indicating similar high thermodynamic and kinetic stabilities to other bis-chelated [Au(P-P)2]+ complexes containing 5- or 6-membered chelate rings. The ionic Au(I) complex 2 and the analogous Ag(I) complex [Ag(dpmma)2]NO3 (3) are highly water soluble. The in vitro cytotoxic activity of 2 was assessed against eight different cell lines and no significant activity was found. The solubility properties and solution behaviour of the complexes are compared to the analogous 1,2-bis(diphenylphosphino)ethane (dppe) complexes and the potential significance of these results to the antitumour properties of chelated 1:2 Au(I)diphosphine complexes are discussed.en_US
dc.publisherElsevier BVen_US
dc.relation.ispartofjournalInorganica Chimica Actaen_US
dc.titleGold(I) and silver(I) complexes of 2,3-bis(diphenylphosphino)maleic acid: structural studies and antitumour activityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.hasfulltextNo Full Text

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