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dc.contributor.authorBerners-Price, Sueen_US
dc.contributor.authorA. Fernandes, Manuelen_US
dc.contributor.authorLayh, Marcusen_US
dc.contributor.authorMahepal, Sherikaen_US
dc.contributor.authorM. Mtotywa, Matolwandileen_US
dc.contributor.authorE.J. Rensburg, Constanceen_US
dc.date.accessioned2017-04-24T08:01:30Z
dc.date.available2017-04-24T08:01:30Z
dc.date.issued2005en_US
dc.date.modified2007-03-19T21:35:54Z
dc.identifier.issn00201693en_US
dc.identifier.urihttp://hdl.handle.net/10072/4919
dc.description.abstractThe 2:1 and 1:2 adducts of Au(I) and 1:2 adducts of Ag(I) with the diphosphine 2,3-bis(diphenylphosphino)maleic acid (dpmaa) have been prepared in high yields. Crystal structures have been determined for the neutral digold complex (AuCl)2(dpmaa) 砲thf (1) and the bis-chelated complex [Au(dpmaa)2]Cl 砈2O 砃H3OH (2). For 1, conformational rigidity imposed by the ethylenic bridge facilitates the formation of short intramolecular Au-Au contacts with no evidence of similar intermolecular contacts. Complex 2 crystallizes with [Au(dpmaa)2]+ cations hydrogen bonded through the carboxyl groups to a water molecule and chloride anion to form a H-bonded chain along the a axis. 31P NMR titration of 1 with dpmaa in acetone shows conversion to 2 at Au:P-P ratios less than 1:1 indicating similar high thermodynamic and kinetic stabilities to other bis-chelated [Au(P-P)2]+ complexes containing 5- or 6-membered chelate rings. The ionic Au(I) complex 2 and the analogous Ag(I) complex [Ag(dpmma)2]NO3 (3) are highly water soluble. The in vitro cytotoxic activity of 2 was assessed against eight different cell lines and no significant activity was found. The solubility properties and solution behaviour of the complexes are compared to the analogous 1,2-bis(diphenylphosphino)ethane (dppe) complexes and the potential significance of these results to the antitumour properties of chelated 1:2 Au(I)diphosphine complexes are discussed.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier BVen_US
dc.publisher.placeNetherlandsen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/504086/description#descriptionen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom4237en_US
dc.relation.ispartofpageto4246en_US
dc.relation.ispartofjournalInorganica Chimica Actaen_US
dc.relation.ispartofvolume358en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode250204en_US
dc.titleGold(I) and silver(I) complexes of 2,3-bis(diphenylphosphino)maleic acid: structural studies and antitumour activityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.rights.copyrightCopyright 2005 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext linksen_AU
gro.date.issued2005
gro.hasfulltextNo Full Text


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