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  • Effects of unconjugated bilirubin on chromosomal damage in individuals with Gilbert's syndrome measured with the micronucleus cytome assay

    Author(s)
    Wallner, M
    Blassnigg, SM
    Marisch, K
    Pappenheim, MT
    Muellner, E
    Moelzer, C
    Nersesyan, A
    Marculescu, R
    Doberer, D
    Knasmueller, S
    Bulmer, AC
    Wagner, KH
    Griffith University Author(s)
    Bulmer, Andrew C.
    Year published
    2012
    Metadata
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    Abstract
    Circulating unconjugated bilirubin (UCB) has been reported to protect against lung and colorectal cancer. The present study aimed to explore, for the first time, whether mildly elevated circulating UCB, as found in Gilbert`s syndrome (GS), is associated with changes of DNA damage. A random 76 individuals, matched for age and gender, were recruited from the general population and allocated into the GS group (UCB =17.1 卻 n = 38) or control group (UCB <17.1 卻 n = 38). Chromosomal and cytological changes were determined in lymphocytes and buccal cells using the cytokinesis-block micronucleus cytome assay (CBMN) and buccal ...
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    Circulating unconjugated bilirubin (UCB) has been reported to protect against lung and colorectal cancer. The present study aimed to explore, for the first time, whether mildly elevated circulating UCB, as found in Gilbert`s syndrome (GS), is associated with changes of DNA damage. A random 76 individuals, matched for age and gender, were recruited from the general population and allocated into the GS group (UCB =17.1 卻 n = 38) or control group (UCB <17.1 卻 n = 38). Chromosomal and cytological changes were determined in lymphocytes and buccal cells using the cytokinesis-block micronucleus cytome assay (CBMN) and buccal micronucleus cytome assay (BMcyt). No significant differences were found between GS subjects and the control group in the CBMN and BMcyt determined endpoints. Subsequently, when age dependency of effects were analysed, lower formation of buccal micronucleated cells (by 73.3%) and buccal nuclear buds (by 70.9%) in the GS subgroup =30 years were found, compared to the GS subgroup <30 years. These findings suggest DNA protection in epithelial tissue of older individuals with GS.
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    Journal Title
    Mutagenesis
    Volume
    27
    Issue
    6
    DOI
    https://doi.org/10.1093/mutage/ges039
    Subject
    Clinical chemistry (incl. diagnostics)
    Cancer diagnosis
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/49247
    Collection
    • Journal articles

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