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dc.contributor.authorWallner, M
dc.contributor.authorBlassnigg, SM
dc.contributor.authorMarisch, K
dc.contributor.authorPappenheim, MT
dc.contributor.authorMuellner, E
dc.contributor.authorMoelzer, C
dc.contributor.authorNersesyan, A
dc.contributor.authorMarculescu, R
dc.contributor.authorDoberer, D
dc.contributor.authorKnasmueller, S
dc.contributor.authorBulmer, AC
dc.contributor.authorWagner, KH
dc.date.accessioned2017-05-03T15:40:14Z
dc.date.available2017-05-03T15:40:14Z
dc.date.issued2012
dc.date.modified2013-03-06T00:32:32Z
dc.identifier.issn0267-8357
dc.identifier.doi10.1093/mutage/ges039
dc.identifier.urihttp://hdl.handle.net/10072/49247
dc.description.abstractCirculating unconjugated bilirubin (UCB) has been reported to protect against lung and colorectal cancer. The present study aimed to explore, for the first time, whether mildly elevated circulating UCB, as found in Gilbert`s syndrome (GS), is associated with changes of DNA damage. A random 76 individuals, matched for age and gender, were recruited from the general population and allocated into the GS group (UCB =17.1 卻 n = 38) or control group (UCB <17.1 卻 n = 38). Chromosomal and cytological changes were determined in lymphocytes and buccal cells using the cytokinesis-block micronucleus cytome assay (CBMN) and buccal micronucleus cytome assay (BMcyt). No significant differences were found between GS subjects and the control group in the CBMN and BMcyt determined endpoints. Subsequently, when age dependency of effects were analysed, lower formation of buccal micronucleated cells (by 73.3%) and buccal nuclear buds (by 70.9%) in the GS subgroup =30 years were found, compared to the GS subgroup <30 years. These findings suggest DNA protection in epithelial tissue of older individuals with GS.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom731
dc.relation.ispartofpageto735
dc.relation.ispartofissue6
dc.relation.ispartofjournalMutagenesis
dc.relation.ispartofvolume27
dc.rights.retentionY
dc.subject.fieldofresearchClinical chemistry (incl. diagnostics)
dc.subject.fieldofresearchCancer diagnosis
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode320202
dc.subject.fieldofresearchcode321102
dc.subject.fieldofresearchcode3214
dc.titleEffects of unconjugated bilirubin on chromosomal damage in individuals with Gilbert's syndrome measured with the micronucleus cytome assay
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorBulmer, Andrew C.


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