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  • Psammaplysin derivatives from the Balinese marine sponge Aplysinella strongylata

    Author(s)
    Mudianta, I Wayan
    Skinner-Adams, Tina
    Andrews, Katherine T
    Davis, Rohan A
    Hadi, Tri A
    Hayes, Patricia Y
    Garson, Mary J
    Griffith University Author(s)
    Andrews, Katherine T.
    Davis, Rohan A.
    Skinner-Adams, Tina
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    Twenty-one new psammaplysin derivatives (4-24) exhibiting a variety of side chains, as well as six previously known psammaplysins, were identified from the Indonesian marine sponge Aplysinella strongylata. The double bond on the side chain of the fatty acid-containing psammaplysins was located by GC-MS analysis of the fatty acid methyl esters and their pyrrolidide derivatives. HPLC and Mosher ester studies confirmed that the isolated metabolites possessing a 19-OH substituent were mixtures of diastereomers. Selected compounds (4, 5, 7, 8, 12, 18, and 22) were screened for in vitro activity against chloroquine-sensitive (3D7) ...
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    Twenty-one new psammaplysin derivatives (4-24) exhibiting a variety of side chains, as well as six previously known psammaplysins, were identified from the Indonesian marine sponge Aplysinella strongylata. The double bond on the side chain of the fatty acid-containing psammaplysins was located by GC-MS analysis of the fatty acid methyl esters and their pyrrolidide derivatives. HPLC and Mosher ester studies confirmed that the isolated metabolites possessing a 19-OH substituent were mixtures of diastereomers. Selected compounds (4, 5, 7, 8, 12, 18, and 22) were screened for in vitro activity against chloroquine-sensitive (3D7) P. falciparum malaria parasites. Of the new psammaplysins, 19-hydroxypsammaplysin E (4) showed the best antimalarial activity, with an IC(50) value of 6.4 卮
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    Journal Title
    Journal of Natural Products
    Volume
    75
    Issue
    12
    DOI
    https://doi.org/10.1021/np300560b
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Medical Parasitology
    Chemical Sciences
    Biological Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/49252
    Collection
    • Journal articles

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