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  • Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation

    Author(s)
    Magolan, Jakob
    Adams, Nathan BP
    Onozuka, Hiroko
    Hungerford, Natasha L
    Esumi, Hiroyasu
    Coster, Mark J
    Griffith University Author(s)
    Coster, Mark J.
    Hungerford, Natasha L.
    Magolan, Jakob
    Adams, Nathan
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient-deprived, resistant cancer cells. Through structure-activity relationship studies, three analogues were identified as lead compounds for the develpoment of molecular probes for the investigation of the mode of action and biological targets of the antiausterity compounds.Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient-deprived, resistant cancer cells. Through structure-activity relationship studies, three analogues were identified as lead compounds for the develpoment of molecular probes for the investigation of the mode of action and biological targets of the antiausterity compounds.
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    Journal Title
    ChemMedChem
    Volume
    7
    Issue
    5
    DOI
    https://doi.org/10.1002/cmdc.201100564
    Subject
    Medicinal and biomolecular chemistry
    Biologically active molecules
    Organic chemistry
    Organic chemical synthesis
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/49282
    Collection
    • Journal articles

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