• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Inhibition of Hypoxia Inducible Factor-2 Transcription: Isolation of Active Modulators from Marine Sponges

    Thumbnail
    View/Open
    GrkovicPUB4.pdf (423.7Kb)
    Author(s)
    McKee, Tawnya C.
    Rabe, Daniel
    Bokesch, Heidi R.
    Grkovic, Tanja
    Whitson, Emily L.
    Diyabalanage, Thushara
    Van Wyk, Albert W. W.
    Marcum, Stephanie R.
    Gardella, Roberta S.
    Gustafson, Kirk R.
    Marston Linehan, W.
    McMahon, James B.
    Bottaro, Donald P.
    Griffith University Author(s)
    Grkovic, Tanja
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    Renal or kidney cancer accounts for about 3% of all cancer cases reported each year in the U.S. Molecular signatures that define the cancer, such as the loss of functional VHL, are found in both sporadic and familial cases of cancer. In clear cell renal cancer, the transcription factor HIF-2a has been shown to have a distinct role in tumorigenesis. Our laboratories developed a cell-based screen to identify modulators of HIF-2a. Screening of the NCI's Natural Product Extract Repository resulted in the identification of 10 sponge extracts, from which 12 compounds were isolated. The biological evaluation of these ...
    View more >
    Renal or kidney cancer accounts for about 3% of all cancer cases reported each year in the U.S. Molecular signatures that define the cancer, such as the loss of functional VHL, are found in both sporadic and familial cases of cancer. In clear cell renal cancer, the transcription factor HIF-2a has been shown to have a distinct role in tumorigenesis. Our laboratories developed a cell-based screen to identify modulators of HIF-2a. Screening of the NCI's Natural Product Extract Repository resulted in the identification of 10 sponge extracts, from which 12 compounds were isolated. The biological evaluation of these compounds will be discussed including evaluation of HIF-1a vs HIF-2a selectivity and the isolated compounds' effects on mRNA from several pathways regulated by HIF.
    View less >
    Journal Title
    Journal of Natural Products
    Volume
    75
    Issue
    9
    DOI
    https://doi.org/10.1021/np300211x
    Copyright Statement
    This document is the Accepted Manuscript version of a published work that appeared in final form in Journal of Natural Products, copyright 2012 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/np300211x
    Subject
    Natural Products Chemistry
    Publication URI
    http://hdl.handle.net/10072/49387
    Collection
    • Journal articles

    Footer

    Social media

    • Facebook
    • Twitter
    • YouTube
    • Instagram
    • Linkedin
    First peoples of Australia
    • Aboriginal
    • Torres Strait Islander

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane
    • Australia