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dc.contributor.authorMcKee, Tawnya C.
dc.contributor.authorRabe, Daniel
dc.contributor.authorBokesch, Heidi R.
dc.contributor.authorGrkovic, Tanja
dc.contributor.authorWhitson, Emily L.
dc.contributor.authorDiyabalanage, Thushara
dc.contributor.authorVan Wyk, Albert W. W.
dc.contributor.authorMarcum, Stephanie R.
dc.contributor.authorGardella, Roberta S.
dc.contributor.authorGustafson, Kirk R.
dc.contributor.authorMarston Linehan, W.
dc.contributor.authorMcMahon, James B.
dc.contributor.authorBottaro, Donald P.
dc.date.accessioned2019-04-09T04:16:16Z
dc.date.available2019-04-09T04:16:16Z
dc.date.issued2012
dc.date.modified2013-03-12T21:46:32Z
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np300211x
dc.identifier.urihttp://hdl.handle.net/10072/49387
dc.description.abstractRenal or kidney cancer accounts for about 3% of all cancer cases reported each year in the U.S. Molecular signatures that define the cancer, such as the loss of functional VHL, are found in both sporadic and familial cases of cancer. In clear cell renal cancer, the transcription factor HIF-2a has been shown to have a distinct role in tumorigenesis. Our laboratories developed a cell-based screen to identify modulators of HIF-2a. Screening of the NCI's Natural Product Extract Repository resulted in the identification of 10 sponge extracts, from which 12 compounds were isolated. The biological evaluation of these compounds will be discussed including evaluation of HIF-1a vs HIF-2a selectivity and the isolated compounds' effects on mRNA from several pathways regulated by HIF.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1632
dc.relation.ispartofpageto1636
dc.relation.ispartofissue9
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume75
dc.rights.retentionY
dc.subject.fieldofresearchNatural Products Chemistry
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode030502
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleInhibition of Hypoxia Inducible Factor-2 Transcription: Isolation of Active Modulators from Marine Sponges
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightThis document is the Accepted Manuscript version of a published work that appeared in final form in Journal of Natural Products, copyright 2012 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/np300211x
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorGrkovic, Tanja


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