dc.contributor.author | McKee, Tawnya C. | |
dc.contributor.author | Rabe, Daniel | |
dc.contributor.author | Bokesch, Heidi R. | |
dc.contributor.author | Grkovic, Tanja | |
dc.contributor.author | Whitson, Emily L. | |
dc.contributor.author | Diyabalanage, Thushara | |
dc.contributor.author | Van Wyk, Albert W. W. | |
dc.contributor.author | Marcum, Stephanie R. | |
dc.contributor.author | Gardella, Roberta S. | |
dc.contributor.author | Gustafson, Kirk R. | |
dc.contributor.author | Marston Linehan, W. | |
dc.contributor.author | McMahon, James B. | |
dc.contributor.author | Bottaro, Donald P. | |
dc.date.accessioned | 2019-04-09T04:16:16Z | |
dc.date.available | 2019-04-09T04:16:16Z | |
dc.date.issued | 2012 | |
dc.date.modified | 2013-03-12T21:46:32Z | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.doi | 10.1021/np300211x | |
dc.identifier.uri | http://hdl.handle.net/10072/49387 | |
dc.description.abstract | Renal or kidney cancer accounts for about 3% of all cancer cases reported each year in the U.S. Molecular signatures that define the cancer, such as the loss of functional VHL, are found in both sporadic and familial cases of cancer. In clear cell renal cancer, the transcription factor HIF-2a has been shown to have a distinct role in tumorigenesis. Our laboratories developed a cell-based screen to identify modulators of HIF-2a. Screening of the NCI's Natural Product Extract Repository resulted in the identification of 10 sponge extracts, from which 12 compounds were isolated. The biological evaluation of these compounds will be discussed including evaluation of HIF-1a vs HIF-2a selectivity and the isolated compounds' effects on mRNA from several pathways regulated by HIF. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1632 | |
dc.relation.ispartofpageto | 1636 | |
dc.relation.ispartofissue | 9 | |
dc.relation.ispartofjournal | Journal of Natural Products | |
dc.relation.ispartofvolume | 75 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Natural Products Chemistry | |
dc.subject.fieldofresearch | Chemical Sciences | |
dc.subject.fieldofresearch | Biological Sciences | |
dc.subject.fieldofresearch | Medical and Health Sciences | |
dc.subject.fieldofresearchcode | 030502 | |
dc.subject.fieldofresearchcode | 03 | |
dc.subject.fieldofresearchcode | 06 | |
dc.subject.fieldofresearchcode | 11 | |
dc.title | Inhibition of Hypoxia Inducible Factor-2 Transcription: Isolation of Active Modulators from Marine Sponges | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | This document is the Accepted Manuscript version of a published work that appeared in final form in Journal of Natural Products, copyright 2012 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/np300211x | |
gro.date.issued | 2012 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Grkovic, Tanja | |