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dc.contributor.authorMurrell, Wayneen_US
dc.contributor.authorFeron, Francoisen_US
dc.contributor.authorWetzig, Andrewen_US
dc.contributor.authorSplatt, Karishaen_US
dc.contributor.authorBellette, Bernadetteen_US
dc.contributor.authorBianco, Johnen_US
dc.contributor.authorPerry, Chrisen_US
dc.contributor.authorLee, Gabrielen_US
dc.contributor.authorMackay-Sim, Alanen_US
dc.contributor.editorGary Schoenwolfen_US
dc.date.accessioned2017-05-03T12:01:33Z
dc.date.available2017-05-03T12:01:33Z
dc.date.issued2005en_US
dc.date.modified2009-09-21T05:49:19Z
dc.identifier.issn10588388en_US
dc.identifier.doi10.1002/dvdy.20360en_AU
dc.identifier.urihttp://hdl.handle.net/10072/4938
dc.description.abstractMultipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone-marrow irradiated hosts and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWiley-Lissen_US
dc.publisher.placeHoboken, New Jerseyen_US
dc.publisher.urihttp://www3.interscience.wiley.com/journal/117927935/grouphome/home.htmlen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom496en_US
dc.relation.ispartofpageto515en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalDevelopmental Dynamicsen_US
dc.relation.ispartofvolume233en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270106en_US
dc.titleMultipotent Stem Cells From Adult Olfactory Mucosaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2005 John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.en_AU
gro.date.issued2005
gro.hasfulltextNo Full Text


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