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dc.contributor.authorMurrell, W
dc.contributor.authorFeron, F
dc.contributor.authorWetzig, A
dc.contributor.authorCameron, N
dc.contributor.authorSplatt, K
dc.contributor.authorBellette, B
dc.contributor.authorBianco, J
dc.contributor.authorPerry, C
dc.contributor.authorLee, G
dc.contributor.authorMackay-Sim, A
dc.contributor.editorGary Schoenwolf
dc.date.accessioned2017-05-03T12:01:33Z
dc.date.available2017-05-03T12:01:33Z
dc.date.issued2005
dc.date.modified2009-09-21T05:49:19Z
dc.identifier.issn1058-8388
dc.identifier.doi10.1002/dvdy.20360
dc.identifier.urihttp://hdl.handle.net/10072/4938
dc.description.abstractMultipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone-marrow irradiated hosts and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherWiley-Liss
dc.publisher.placeHoboken, New Jersey
dc.publisher.urihttp://www3.interscience.wiley.com/journal/117927935/grouphome/home.html
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom496
dc.relation.ispartofpageto515
dc.relation.ispartofissue2
dc.relation.ispartofjournalDevelopmental Dynamics
dc.relation.ispartofvolume233
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode06
dc.titleMultipotent Stem Cells From Adult Olfactory Mucosa
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2005 John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorCameron, Nicholas
gro.griffith.authorMackay-Sim, Alan
gro.griffith.authorMurrell, Wayne G.
gro.griffith.authorBianco, John I.
gro.griffith.authorFeron, Francois
gro.griffith.authorWetzig, Andrew R.
gro.griffith.authorSplatt, Karisha J.
gro.griffith.authorBellette, Bernadette


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