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dc.contributor.authorWells, Christine
dc.contributor.authorRavasi, Timothy
dc.contributor.authorA. Hume, David
dc.date.accessioned2017-05-03T15:01:00Z
dc.date.available2017-05-03T15:01:00Z
dc.date.issued2005
dc.date.modified2009-04-16T06:52:32Z
dc.identifier.issn07415400
dc.identifier.doi10.1189/jlb.1204710
dc.identifier.urihttp://hdl.handle.net/10072/4960
dc.description.abstractAn effective immune system requires rapid and appropriate activation of inflammatory mechanisms but equally rapid and effective resolution of the inflammatory state. A review of the canonical host response to gram-negative bacteria, the lipopolysaccharide-Toll-like receptor 4 signaling cascade, highlights the induction of repressors that act at each step of the activation process. These inflammation suppressor genes are characterized by their induction in response to pathogen, typically late in the macrophage activation program, and include an expanding class of dominant-negative proteins derived from alternate splicing of common signaling components. Despite the expanse of anti-inflammatory mechanisms available to an activated macrophage, the frailty of this system is apparent in the large numbers of genes implicated in chronic inflammatory diseases. This apparent lack of redundancy between inflammation suppressor genes is discussed with regard to evolutionary benefits in generating a heterogeneous population of immune cells and consequential robustness in defense against new and evolving pathogens.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFederation of American Societies for Experimental Biology
dc.publisher.placeUSA
dc.publisher.urihttp://www.jleukbio.org/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom9
dc.relation.ispartofpageto13
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Leukocyte Biology
dc.relation.ispartofvolume78
dc.rights.retentionN
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1107
dc.titleInflammation suppressor genes: please switch out all the lights
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorWells, Christine


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