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  • Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia

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    Author(s)
    Kartasurya, Martha I
    Ahmed, Faruk
    Subagio, Hertanto W
    Rahfiludin, Muhammad Z
    Marks, Geoffrey C
    Griffith University Author(s)
    Ahmed, Faruk
    Year published
    2012
    Metadata
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    Abstract
    Zn supplementation has shown inconsistent effects on respiratory morbidity in young children in developing countries. Few studies have focused on upper respiratory tract infection (URTI), a frequent cause of morbidity in this group, and potential benefit from Zn supplementation or factors that influence its efficacy. We investigated the effects of Zn supplementation on URTI before and after vitamin A supplementation. This randomised double-blinded controlled Zn supplementation study was conducted on 826 children aged 2-5 years. Placebo or Zn (10 mg/d) was given in syrup daily for 4 months, with 200 000 IU vitamin A (60 mg ...
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    Zn supplementation has shown inconsistent effects on respiratory morbidity in young children in developing countries. Few studies have focused on upper respiratory tract infection (URTI), a frequent cause of morbidity in this group, and potential benefit from Zn supplementation or factors that influence its efficacy. We investigated the effects of Zn supplementation on URTI before and after vitamin A supplementation. This randomised double-blinded controlled Zn supplementation study was conducted on 826 children aged 2-5 years. Placebo or Zn (10 mg/d) was given in syrup daily for 4 months, with 200 000 IU vitamin A (60 mg retinol) given to all children at 2 months. Health workers visited children every 3 d for compliance and morbidity information. We found that 84% of children experienced URTI during the study. Zn supplementation reduced the percentage of days with URTI (12% reduction; P찷09), with greater impact following vitamin A supplementation (20% reduction; P찷01). Vitamin A supplementation was associated with a decreased number but an increased duration of URTI episodes. We conclude that Zn combined with vitamin A supplementation significantly reduced the percentage of days with URTI in a population of preschool Indonesian children with marginal nutritional status. The results suggest that vitamin A status modifies the efficacy of Zn supplementation on URTI.
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    Journal Title
    British Journal of Nutrition
    Volume
    108
    Issue
    12
    DOI
    https://doi.org/10.1017/S0007114512000499
    Copyright Statement
    © 2012 The Authors. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Animal production
    Food sciences
    Nutrition and dietetics
    Public health nutrition
    Publication URI
    http://hdl.handle.net/10072/49611
    Collection
    • Journal articles

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