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  • Alternative chitosan based drug delivery system to fight oral mucositis: Synergy of conventional and bioactives towards the optimal solution

    Author(s)
    Perchyonok, Tamara
    Zhang, Shengmiao
    Oberholzer, Theunis
    Griffith University Author(s)
    Oberholzer, Theunis
    Perchyonok, Tamara
    Year published
    2012
    Metadata
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    Abstract
    Chitosan based novel occlusive bioadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan, suitable surfactants (Cetyl trimethylammonium bromide and Polyquaternium-1 (Polyquad and Propolis ethanolic extract were developed and evaluated in this investigation. The positive synergy was observed combined the antifungal and antioxidant capacity of synthetic and natural biomaterials into functional biocompatible gel. The in vitro antioxidant capacity (free radical scavenging by ORAC and intrinsic reducing capacity by Folin-Ciocalteu Method) was quantified and the influence of antioxidant capacity of ...
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    Chitosan based novel occlusive bioadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan, suitable surfactants (Cetyl trimethylammonium bromide and Polyquaternium-1 (Polyquad and Propolis ethanolic extract were developed and evaluated in this investigation. The positive synergy was observed combined the antifungal and antioxidant capacity of synthetic and natural biomaterials into functional biocompatible gel. The in vitro antioxidant capacity (free radical scavenging by ORAC and intrinsic reducing capacity by Folin-Ciocalteu Method) was quantified and the influence of antioxidant capacity of Propolis extract on the rate of release of nystatin, from chitosan based material was investigated. These copolymer systems are able to release the drug over several weeks and therefore may be useful as a drug carrier in the treatment of oral mucosatis
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    Journal Title
    Current Nanoscience
    Volume
    8
    Issue
    4
    DOI
    https://doi.org/10.2174/157341312801784320
    Subject
    Nanotechnology
    Dental therapeutics, pharmacology and toxicology
    Publication URI
    http://hdl.handle.net/10072/49642
    Collection
    • Journal articles

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