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  • RNA Interference for the Treatment of Papillomavirus Disease

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    Author(s)
    Singhania, Richa
    Khairuddin, Norliana
    Clarke, Daniel
    McMillan, Nigel Aj
    Griffith University Author(s)
    McMillan, Nigel
    Clarke, Daniel
    Year published
    2012
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    Abstract
    Human Papillomavirus (HPV)-induced diseases are a significant burden on our healthcare system and current therapies are not curative. Vaccination provides significant prophylactic protection but effective therapeutic treatments will still be required. RNA interference (RNAi) has great promise in providing highly specific therapies for all HPV diseases yet this promise has not been realised. Here we review the research into RNAi therapy for HPV in vitro and in vivo and examine the various targets and outcomes. We discuss the idea of using RNAi with current treatments and address delivery of RNAi, the major issue holding back ...
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    Human Papillomavirus (HPV)-induced diseases are a significant burden on our healthcare system and current therapies are not curative. Vaccination provides significant prophylactic protection but effective therapeutic treatments will still be required. RNA interference (RNAi) has great promise in providing highly specific therapies for all HPV diseases yet this promise has not been realised. Here we review the research into RNAi therapy for HPV in vitro and in vivo and examine the various targets and outcomes. We discuss the idea of using RNAi with current treatments and address delivery of RNAi, the major issue holding back clinical adoption. Finally, we present our view of a potential path to the clinic.
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    Journal Title
    The Open Virology Journal
    Volume
    6
    Issue
    Suppl 2: M6
    DOI
    https://doi.org/10.2174/1874357901206010204
    Copyright Statement
    © The Author(s) 2012. For information about this journal please refer to the publisher’s website or contact the authors. Articles are licensed under the terms of the Creative Commons Attribution non-commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Medical and Health Sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/49714
    Collection
    • Journal articles

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