Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II
Abstract
This manuscript reports the identification of a novel series of mono- and bis- benzene sulphonamides with potent binding affinity for bovine carbonic anhydrase II (bCAII). These compounds exhibited nanomolar equilibrium dissociation constants with Ki's ranging from 4.7 to 9.3 nM. All compounds were ester derivatives of the weak affinity bCAII inhibitor, 4-carboxybenzenesulphonamide. Structure-activity relationships for this novel series of compounds are discussed.This manuscript reports the identification of a novel series of mono- and bis- benzene sulphonamides with potent binding affinity for bovine carbonic anhydrase II (bCAII). These compounds exhibited nanomolar equilibrium dissociation constants with Ki's ranging from 4.7 to 9.3 nM. All compounds were ester derivatives of the weak affinity bCAII inhibitor, 4-carboxybenzenesulphonamide. Structure-activity relationships for this novel series of compounds are discussed.
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Journal Title
Bioorganic and Medicinal Chemistry Letters
Volume
15
Issue
24
Publisher URI
Copyright Statement
© 2005 Elsevier. Please refer to the journal's website for access to the definitive, published version.
Subject
Medicinal and biomolecular chemistry
Organic chemistry
Pharmacology and pharmaceutical sciences