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  • Effect of Coffee Combining Green Coffee Bean Constituents with Typical Roasting Products on the Nrf2/ARE Pathway in Vitro and in Vivo

    Author(s)
    Volz, Nadine
    Boettler, Ute
    Winkler, Swantje
    Teller, Nicole
    Schwarz, Chrisoph
    Bakuradze, Tamara
    Eizenbrand, Gerhard
    Haupt, Larisa
    Griffiths, Lyn
    Stiebitz, Herbert
    Bytof, Gerhard
    Lantz, Ingo
    Lang, Roman
    Hofmann, Thomas
    Somoza, Veronika
    Marko, Doris
    Griffith University Author(s)
    Haupt, Larisa
    Griffiths, Lyn
    Year published
    2012
    Metadata
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    Abstract
    This study investigated Nrf2-activating properties of a coffee blend combining raw coffee bean constituents with 5-O-caffeoylquinic acid (CGA) as a lead component with typical roasting products such as N-methylpyridinium (NMP). In cell culture (HT29) the respective coffee extract (CN-CE) increased nuclear Nrf2 translocation and enhanced the transcription of ARE-dependent genes as exemplified for NAD(P)H:quinone oxidoreductase and glutathione-S-transferase (GST)A1, reflected in the protein level by an increase in GST enzyme activity. In a pilot human intervention study (29 healthy volunteers), daily consumption of 750 mL of ...
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    This study investigated Nrf2-activating properties of a coffee blend combining raw coffee bean constituents with 5-O-caffeoylquinic acid (CGA) as a lead component with typical roasting products such as N-methylpyridinium (NMP). In cell culture (HT29) the respective coffee extract (CN-CE) increased nuclear Nrf2 translocation and enhanced the transcription of ARE-dependent genes as exemplified for NAD(P)H:quinone oxidoreductase and glutathione-S-transferase (GST)A1, reflected in the protein level by an increase in GST enzyme activity. In a pilot human intervention study (29 healthy volunteers), daily consumption of 750 mL of CN-coffee for 4 weeks increased Nrf2 transcription in peripheral blood lymphocytes on average. However, the transcriptional response pattern of Nrf2/ARE-dependent genes showed substantial interindividual variations. The presence of SNPs in the Nrf2-promoter, reported recently, as well as the detection of GSTT1*0 (null) genotypes in the study collective strengthens the hypothesis that coffee acts as a modulator of Nrf2-dependent gene response in humans, but genetic polymorphisms play an important role in the individual response pattern.
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    Journal Title
    Journal of Agricultural and Food Chemistry
    Volume
    60
    Issue
    38
    DOI
    https://doi.org/10.1021/jf302258u
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Medical and Health Sciences not elsewhere classified
    Chemical Sciences
    Agricultural and Veterinary Sciences
    Engineering
    Publication URI
    http://hdl.handle.net/10072/49751
    Collection
    • Journal articles

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