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dc.contributor.authorVolz, Nadineen_US
dc.contributor.authorBoettler, Uteen_US
dc.contributor.authorWinkler, Swantjeen_US
dc.contributor.authorTeller, Nicoleen_US
dc.contributor.authorSchwarz, Chrisophen_US
dc.contributor.authorBakuradze, Tamaraen_US
dc.contributor.authorEizenbrand, Gerharden_US
dc.contributor.authorHaupt, Larisaen_US
dc.contributor.authorGriffiths, Lynen_US
dc.contributor.authorStiebitz, Herberten_US
dc.contributor.authorBytof, Gerharden_US
dc.contributor.authorLantz, Ingoen_US
dc.contributor.authorLang, Romanen_US
dc.contributor.authorHofmann, Thomasen_US
dc.contributor.authorSomoza, Veronikaen_US
dc.contributor.authorMarko, Dorisen_US
dc.description.abstractThis study investigated Nrf2-activating properties of a coffee blend combining raw coffee bean constituents with 5-O-caffeoylquinic acid (CGA) as a lead component with typical roasting products such as N-methylpyridinium (NMP). In cell culture (HT29) the respective coffee extract (CN-CE) increased nuclear Nrf2 translocation and enhanced the transcription of ARE-dependent genes as exemplified for NAD(P)H:quinone oxidoreductase and glutathione-S-transferase (GST)A1, reflected in the protein level by an increase in GST enzyme activity. In a pilot human intervention study (29 healthy volunteers), daily consumption of 750 mL of CN-coffee for 4 weeks increased Nrf2 transcription in peripheral blood lymphocytes on average. However, the transcriptional response pattern of Nrf2/ARE-dependent genes showed substantial interindividual variations. The presence of SNPs in the Nrf2-promoter, reported recently, as well as the detection of GSTT1*0 (null) genotypes in the study collective strengthens the hypothesis that coffee acts as a modulator of Nrf2-dependent gene response in humans, but genetic polymorphisms play an important role in the individual response pattern.en_US
dc.publisherAmerican Chemical Societyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofjournalJournal of Agricultural and Food Chemistryen_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.titleEffect of Coffee Combining Green Coffee Bean Constituents with Typical Roasting Products on the Nrf2/ARE Pathway in Vitro and in Vivoen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.en_US
gro.hasfulltextNo Full Text
gro.griffith.authorHaupt, Larisa
gro.griffith.authorGriffiths, Lyn

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