Immune Consequences of Protracted Host-Tumor Interactions in a Transgenic Mouse Model of Mammary Carcinoma
MetadataShow full item record
A transgenic mouse model of autochthonous mammary carcinoma was chosen to study the impact of tumor progression on the immune system over an extended period. We found: i) that splenocyte numbers, particularly myeloid cells, increased concurrently with tumor burden; ii) the percentage of tumor-infiltrating Treg cells was similar to that in human breast cancer; iii) suppressed T cell proliferation and cytokine production and; iv) significantly elevated MCP-1 and TNF-a in the sera of tumor-bearing mice. The modified immune status in these tumor-bearing hosts is consistent with a "syndrome" that likely impacts the efficacy of cancer immunosurveillance and response to therapy.
© 2008 Informa Healthcare. This is an electronic version of an article published in Cancer Investigation, Vol. 26(3), 2008, pp. 237-249. Cancer Investigation is available online at: http://informahealthcare.com with the open URL of your article.