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dc.contributor.authorBornaghi, LF
dc.contributor.authorPoulsen, SA
dc.date.accessioned2017-05-03T11:45:33Z
dc.date.available2017-05-03T11:45:33Z
dc.date.issued2005
dc.date.modified2009-12-07T07:53:58Z
dc.identifier.issn0040-4039
dc.identifier.doi10.1016/j.tetlet.2005.03.126
dc.identifier.urihttp://hdl.handle.net/10072/4977
dc.description.abstractFischer glycosylation has been used for decades for the synthesis of simple alkyl and aryl glycosides from free sugars. The reaction proceeds under reflux in the presence of catalytic acid with the alcohol as solvent. The main deficiency of this reaction is the long reaction time required. In this study microwave heating has been utilised for the Fischer glycosylation reaction of N-acetyl-d-glucosamine, N-acetyl-d-galactosamine, d-glucose, d-galactose and d-mannose with a variety of alcohols (methanol, ethanol, benzyl alcohol and allyl alcohol). Remarkable acceleration of the glycosylation reactions (minutes compared to hours) over conventional reflux heating was observed with good yields and production of the a-glycoside as the dominant product.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent77990 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier - Pergamon
dc.publisher.placeUK
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/233/description#description
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3485
dc.relation.ispartofpageto3488
dc.relation.ispartofjournalTetrahedron Letters
dc.relation.ispartofvolume46
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.titleMicrowave-accelerated Fischer glycosylation.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2005 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
gro.date.issued2005
gro.hasfulltextFull Text
gro.griffith.authorPoulsen, Sally-Ann


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