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  • Occult Hepatitis B Virus (HBV) Infection: a Global Challenge for Medicine

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    Author(s)
    Assar, Shokrollah
    Arababadi, Mohammad Kazemi
    Ahmadabadi, Behzad Nasiri
    Salehi, Mansoor
    Kennedy, Derek
    Griffith University Author(s)
    Kennedy, Derek D.
    Year published
    2012
    Metadata
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    Abstract
    Hepatitis B virus (HBV) is a serious risk as a disease that can be spread through blood transfusion. Occult hepatitis B infection (OBI) is defined in a patient with the presence of HBV-DNA but a lack of HBsAg in the serum and hepatocytes. OBI can be considered as a high potential risk factor for inducing post transfusion hepatitis (PTH), hepatocellular carcinoma (HCC), cirrhosis, and reactivation of the HBV. Recently, several investigations from various regions of the world have reported PTH as well as HCC and cirrhosis among blood recipients with diseases such as thalassemia and other disorders requiring regular hemodialysis. ...
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    Hepatitis B virus (HBV) is a serious risk as a disease that can be spread through blood transfusion. Occult hepatitis B infection (OBI) is defined in a patient with the presence of HBV-DNA but a lack of HBsAg in the serum and hepatocytes. OBI can be considered as a high potential risk factor for inducing post transfusion hepatitis (PTH), hepatocellular carcinoma (HCC), cirrhosis, and reactivation of the HBV. Recently, several investigations from various regions of the world have reported PTH as well as HCC and cirrhosis among blood recipients with diseases such as thalassemia and other disorders requiring regular hemodialysis. This form of hepatitis also causes complications for individuals that are co-infected with other viruses such as HCV and HIV. Because of its extreme disease potential, OBI can be considered a high risk for PTH, HCC, and cirrhosis. Therefore, an understanding of the prevalence of OBI among blood donors is a critical strategy in most transfusion services. This review addresses the recent information regarding the prevalence of OBI worldwide, with an additional focus on Iranian blood donors.
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    Journal Title
    Clinical Laboratory
    Volume
    58
    Issue
    11-12
    DOI
    https://doi.org/10.7754/Clin.Lab.2012.120119
    Copyright Statement
    © 2012 Clinical Laboratory Publications. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Clinical sciences
    Infectious diseases
    Publication URI
    http://hdl.handle.net/10072/49831
    Collection
    • Journal articles

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