• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Dietary salt loading impairs arterial vascular reactivity

    Author(s)
    Todd, Alwyn
    MacGinley, Robert
    Schollum, John
    Johnson, Richard
    Williams, Sheila
    Sutherland, Wayne
    Mann, Jim
    Walker, Robert
    Griffith University Author(s)
    Todd, Alwyn S.
    Year published
    2010
    Metadata
    Show full item record
    Abstract
    Background: Studies of sodium have shown improvements in vascular function and blood pressure (BP). The effect of chronic sodium loading from a low-sodium diet to a Western diet on vascular function and BP has been less well studied. Objective: The objective was to examine the effects of dietary salt intake on vascular function and BP. Design: Thirty-five hypertensive volunteers met the inclusion criteria. After a 2-wk run-in with a low-sodium diet (60 mmol/d), the participants maintained their diets and were randomly assigned to receive sequentially 1 of 3 interventions for 4 wk, with a 2-wk washout between interventions: ...
    View more >
    Background: Studies of sodium have shown improvements in vascular function and blood pressure (BP). The effect of chronic sodium loading from a low-sodium diet to a Western diet on vascular function and BP has been less well studied. Objective: The objective was to examine the effects of dietary salt intake on vascular function and BP. Design: Thirty-five hypertensive volunteers met the inclusion criteria. After a 2-wk run-in with a low-sodium diet (60 mmol/d), the participants maintained their diets and were randomly assigned to receive sequentially 1 of 3 interventions for 4 wk, with a 2-wk washout between interventions: sodium-free tomato juice (A), tomato juice containing 90 mmol Na (B), and tomato juice containing 140 mmol Na (C). The outcomes were changes in pulse wave velocity (PWV), systolic BP (SBP), and diastolic BP (DBP). Results: The difference in PWV between interventions B and Awas 0.39 m/s (95% CI: 0.18, 0.60 m/s; P 0.001) and between C and A was 0.35 m/s (95% CI: 0.13, 0.57 m/s; P 0.01). Differences in SBP and DBP between interventions B and A were 4.4 mm Hg (95% CI: 1.2, 7.8 mm Hg; P 0.01) and 2.4 mm Hg (95% CI: 0.8, 4.1 mm Hg; P 0.001), respectively, and between interventions C and Awere 5.6 mm Hg (95% CI: 2.7, 8.4 mm Hg; P 0.01) and 3.3 mm Hg (95% CI: 1.5, 5.0 mm Hg; P 0.001), respectively. Changes in PWV correlated with changes in SBP (r = 0.52) and DBP (r = 0.58). Conclusions: Dietary salt loading produced significant increases in PWV and BP in hypertensive volunteers. Correlations between BP and PWV suggest that salt loading may have a BP-independent effect on vascular wall function. This further supports the importance of dietary sodium restriction in the management of hypertension. This trial was registered with the Australian and New Zealand Clinical Trials Registry as ACTRN12609000161224. Am J Clin Nutr 2010;91:557-64.
    View less >
    Journal Title
    American Journal of Clinical Nutrition
    Volume
    91
    Issue
    3
    Publisher URI
    http://ajcn.nutrition.org/content/91/3/557.short
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Clinical and Sports Nutrition
    Engineering
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/49835
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander