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dc.contributor.authorYoung, Megan K
dc.contributor.authorNg, Shu-Kay
dc.contributor.authorMellick, George
dc.contributor.authorScuffham, Paul A
dc.date.accessioned2017-05-03T14:10:40Z
dc.date.available2017-05-03T14:10:40Z
dc.date.issued2013
dc.date.modified2014-08-28T22:59:46Z
dc.identifier.issn0962-9343
dc.identifier.doi10.1007/s11136-012-0231-6
dc.identifier.urihttp://hdl.handle.net/10072/49853
dc.description.abstractPurpose The EuroQoL (EQ-5D) is ideal to compare quality of life across conditions. However, the Parkinson's Disease Questionnaire (PDQ-39) is often the only qualityof- life instrument used in Parkinson's disease research. We aimed to identify associations between PDQ-39 domains and EQ-5D domains, and compare different methods of developing a function to map the PDQ-39 to EQ-5D scores. Methods Adults with Parkinson's disease self-completed both instruments. Ordinal regression identified associations between PDQ-39 domain scores and each EQ-5D domain. Modeling (n = 80) and validation sets (n = 16) were randomly generated. Overall performance of four methods of mapping the PDQ-39 to EQ-5D scores (using PDQ-39 domains and total score in ordinal and linear regression) was assessed with the validation set, followed by assessing the equivalence of observed and predicted EQ-5D scores on the full dataset controlling for sociodemographic factors. Results Different sets of PDQ-39 domains were associated with each EQ-5D domain. For example, PDQ-39 ''Activities of Daily Living'' and ''Social Support'' were associated with EQ-5D ''Personal Care,'' while PDQ-39 ''Emotional Well-being'' was associated with EQ-5D ''Anxiety/Depression.'' Over one-third (37.5 %) of predictions from ordinal regressions had an error /0.01 % (compared to 6.3 % for linear regressions). The EQ-5D scores predicted with ordinal regression using PDQ-39 domains were similar in distribution and association with sociodemographic factors to the observed EQ-5D scores. Conclusions Of the four methods tested, using PDQ-39 domains in ordinal regression was superior for mapping EQ-5D scores. The function reported here may prove particularly useful for cost-utility analyses comparing Parkinson's disease with other conditions.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1065
dc.relation.ispartofpageto1072
dc.relation.ispartofissue5
dc.relation.ispartofjournalQuality of Life Research
dc.relation.ispartofvolume22
dc.rights.retentionY
dc.subject.fieldofresearchNeurology and neuromuscular diseases
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchHuman society
dc.subject.fieldofresearchcode320905
dc.subject.fieldofresearchcode42
dc.subject.fieldofresearchcode44
dc.titleMapping of the PDQ-39 to EQ-5D scores in patients with Parkinson’s disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George
gro.griffith.authorScuffham, Paul A.
gro.griffith.authorNg, Shu Kay Angus


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