The Transcriptional Landscape of the Mammalian Genome

Author(s)
Carninci, P.
Mattick, J.
Hume, D.
Wahlestedt, C.
Suzuki, H.
Liu, E.
Ravasi, T.
Wells, Christine
Lenhard, B.
Frith, M.
Gough, J.
Bajic, V.
Bult, C.
Quackenbush, J.
Hayashizaki, Y.
Kasukawa, T.
Katayama, S.
Maeda, N.
Kodzius, R.
Shimokawa, K.
Brenner, S.
Batalov, S.
Forrest, A. R.
Zavolan, M.
et al.
Griffith University Author(s)
Year published
2005
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Abstract
This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few ...
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Journal Title
Science
Volume
309
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© 2005 AAAS. Self-archiving of the author-manuscript version in an institutional repository is not yet supported by this publisher. Use hypertext link above to access the journal website.
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