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  • Novel diversely substituted 1-heteroaryl-2-imidazolines for fragment-based drug discovery

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    Author(s)
    Krasavin, Mikhail
    Griffith University Author(s)
    Krasavin, Mikhail
    Year published
    2012
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    Abstract
    A palladium-catalyzed Buchwald-Hartwig arylation protocol has been applied to achieve high-yielding N-heteroarylation of a diverse set of privileged 2-imidazolines. The resulting compounds are of interest as a novel type of molecular tool for fragment-based drug discovery. The potential for combining two 2-imidazoline moieties in a heteroarene-linked dimer via sequential Pd-catalyzed arylation has been demonstratedA palladium-catalyzed Buchwald-Hartwig arylation protocol has been applied to achieve high-yielding N-heteroarylation of a diverse set of privileged 2-imidazolines. The resulting compounds are of interest as a novel type of molecular tool for fragment-based drug discovery. The potential for combining two 2-imidazoline moieties in a heteroarene-linked dimer via sequential Pd-catalyzed arylation has been demonstrated
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    Journal Title
    Tetrahedron Letters
    Volume
    53
    Issue
    23
    DOI
    https://doi.org/10.1016/j.tetlet.2012.03.122
    Copyright Statement
    © 2012 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Medicinal and Biomolecular Chemistry not elsewhere classified
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Publication URI
    http://hdl.handle.net/10072/50027
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    • Journal articles

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