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dc.contributor.authorvon Itzstein, Marken_US
dc.contributor.editorMark von Itzsteinen_US
dc.date.accessioned2017-05-03T15:55:47Z
dc.date.available2017-05-03T15:55:47Z
dc.date.issued2012en_US
dc.date.modified2013-04-04T03:17:25Z
dc.identifier.isbn9783764389260en_US
dc.identifier.doi10.1007/978-3-7643-8927-7en_US
dc.identifier.urihttp://hdl.handle.net/10072/50182
dc.description.abstractInfluenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.en_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherSpringeren_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://www.springerlink.com/books/en_US
dc.relation.ispartofstudentpublicationNen_US
dc.rights.retentionNen_US
dc.subject.fieldofresearchInfectious Agentsen_US
dc.subject.fieldofresearchcode060502en_US
dc.titleInfluenza Virus Sialidase - A Drug Discovery Targeten_US
dc.typeBooken_US
dc.type.descriptionA3 - Editeden_US
dc.type.codeA - Booksen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark


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