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dc.contributor.authorMann, MC
dc.contributor.authorThomson, RJ
dc.contributor.authorvon Itzstein, M
dc.contributor.editorDr D L Boger
dc.date.accessioned2017-10-30T12:30:22Z
dc.date.available2017-10-30T12:30:22Z
dc.date.issued2004
dc.date.modified2009-10-19T05:23:51Z
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2004.08.064
dc.identifier.urihttp://hdl.handle.net/10072/5049
dc.description.abstractA novel approach to the synthesis of ߭glycosides of N-acetyl-D-glucosaminuronic acid, in six steps and good overall yield from N-acetyl-D-glucosamine, has been developed. The key synthetic step was the Lewis acid mediated O-glycosidation of methyl 1,3,4-tri-O-pivaloyl-N-acetyl-D-glucosaminuronate (11). Elaboration of glucosaminuronides 15 and 18 provided novel sialylmimetics 21 and 22, which showed inhibition of Vibrio cholerae sialidase.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon
dc.publisher.placeUK
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/972/description#description
dc.relation.ispartofpagefrom5555
dc.relation.ispartofpageto5558
dc.relation.ispartofjournalBiorganic & Medicinal Chemistry Letters
dc.relation.ispartofvolume14
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode1115
dc.titleAn efficient approach to N-acetyl-D-glucosaminuronic acid-based sialylmimetics as potential sialidase inhibitors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorThomson, Robin J.
gro.griffith.authorMann, Maretta C.


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